Evidence map›Paper›PMID 36294666›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

The Effects of Sex and Strain on

Nikeya L Macioce-Tisdale, Alan Ashbaugh, Keeley Hendrix, Margaret S Collins, Aleksey Porollo, Melanie T Cushion

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Journal of fungi (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikeya L Macioce-TisdaleDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0002-5919-129X
Alan AshbaughDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0001-8373-439X
Keeley HendrixDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Margaret S CollinsDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Aleksey PorolloCenter for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-3202-5099
Melanie T CushionDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0001-6621-2784
Cincinnati VA Medical Center · USCincinnati Children's Hospital Medical Center · US

Funding

The role of sex in the life cycle and transmission of PneumocystisR01HL146266 · NHLBI · UNIVERSITY OF CINCINNATI · PI CUSHION, MELANIE T · 2019 to 2022
$1.9M
The role of sex in the life cycle of PneumocystisI01BX004441 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI ALAN George Smulian · 2019 to 2026
–
BLR&D Research Career Scientist Award ApplicationIK6BX005232 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI Melanie T Cushion · 2020 to 2026
–
BLRD VA I01 BX004441BLRD VA IK6 BX005232NHLBI NIH HHS R01 HL146266NIH HHS R01 HL1119190 and Administrative Supplement for Research on Sex/Gender DifferencesVeterans Affairs Biomedical Research Program I01BX000523
6 · The paper itself

Abstract

Many preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies.

methodsPer this mandate, we examined the lung burdens of

resultsFemales in each strain had higher infection burdens compared to males at the later time points.

conclusionFemales should be included in experimental models studying

Indexed as

AIDS-relatedexperimental designPneumocystispneumoniasex differences

Identifiers

PMID36294666
PMCPMC9605296
OpenAlexW4306848277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.