ReviewJournal of fungi (Basel, Switzerland)2022
Management of Filamentous Fungal Keratitis: A Pragmatic Approach.
Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Vitamin C enhances corneal fungal infection treatment in mice via chemotaxis and anti-inflammation.Antimicrobial agents and chemotherapy · 2026Article
- Argon Laser Phototherapy as an Adjunctive Treatment for Refractory Fungal Keratitis: A Retrospective Case Series.Cureus · 2025Article
- Medical interventions for fungal keratitis.The Cochrane database of systematic reviews · 2025Article
- Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy.Mycopathologia · 2025Article
- Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.Journal of ophthalmic inflammation and infection · 2025Article
- Fabrication of nanozyme thixotropic anionic hydrogel for treating fungal keratitis by Dectin-1/p38 pathway.Applied microbiology and biotechnology · 2025Article
- Nanoemulsion Carriers for Ocular Fungal Infection: Main Emphasis on Keratomycosis.Pharmaceutical nanotechnology · 2025Review
- Intracameral voriconazole for severe fungal keratitis: a case series.Arquivos brasileiros de oftalmologia · 2025Article
- Ocular scedosporiosis: A case series.American journal of ophthalmology case reports · 2024Article
- Amphotericin B Ocular Films for Fungal Keratitis and a Novel 3D-Printed Microfluidic Ocular Lens Infection Model.Journal of fungi (Basel, Switzerland) · 2024Article
- Efficacy of the Combined Intrastromal Injection of Voriconazole and Amphotericin B in Recalcitrant Fungal Keratitis.Microorganisms · 2024Article
- Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis.Inflammopharmacology · 2024Article
- Recent Advances in Diagnosis and Treatment Approaches in Fungal Keratitis: A Narrative Review.Microorganisms · 2024Review
- CD3ε of a pan T cell marker involved in mouseInternational journal of ophthalmology · 2024Article
- Plumbagin inhibits fungal growth, HMGB1/LOX-1 pathway and inflammatory factors inFrontiers in microbiology · 2024Article
- [Uveitis complicated by Scedosporium apiospermum sensu stricto: relevance of early diagnosis and its multidisciplinary management].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery.Gels (Basel, Switzerland) · 2023Article
- The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection.PLoS pathogens · 2023Article
- Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models ofAntimicrobial agents and chemotherapy · 2023Article
- Immunity to pathogenic fungi in the eye.Seminars in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Filamentous fungal infections of the cornea known as filamentous fungal keratitis (FK) are challenging to treat. Topical natamycin 5% is usually first-line treatment following the results of several landmark clinical trials. However, even when treated intensively, infections may progress to corneal perforation. Current topical antifungals are not always effective and are often unavailable. Alternatives topical therapies to natamycin include voriconazole, chlorhexidine, amphotericin B and econazole. Surgical therapy, typically in the form of therapeutic penetrating keratoplasty, may be required for severe cases or following corneal perforation. Alternative treatment strategies such as intrastromal or intracameral injections of antifungals may be used. However, there is often no clear treatment strategy and the evidence to guide therapy is often lacking. This review describes the different treatment options and their evidence and provides a pragmatic approach to the management of fungal keratitis, particularly for clinicians working in tropical, low-resource settings where fungal keratitis is most prevalent.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.