Evidence map›Paper›PMID 36294612›Full record

ReviewJournal of fungi (Basel, Switzerland)2022

The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease.

Lottie Brown, Guyguy Kamwiziku, Rita O Oladele, Matthew J Burton, N Venkatesh Prajna, Thomas M Leitman, David W Denning

Abstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Prevalence and diversity of antifungal resistance inAntimicrobial agents and chemotherapy · 2025
    Article
  3. The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Cold atmospheric plasma inactivatesJournal of medical microbiology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. CD3ε of a pan T cell marker involved in mouseInternational journal of ophthalmology · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Emerging treatments in fungal keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lottie BrownManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0001-9896-8682
Guyguy KamwizikuKinshasa University Hospital, M8R4+CF3, Kinshasa P.O. Box 8842, Democratic Republic of the Congo.ORCID 0000-0001-6770-3999
Rita O OladeleDepartment of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos 101017, Nigeria.
Matthew J BurtonInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
N Venkatesh PrajnaAravind Eye Hospitals and Postgraduate Institute of Ophthalmology, Madurai 625020, Tamil Nadu, India.
Thomas M LeitmanDepartments of Ophthalmology, Epidemiology & Biostatistics, University of California, San Francisco, CA 94143, USA.
David W DenningManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0001-5626-2251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amongst the treatable cause of blindness among young people, fungal keratitis ranks high. There are an estimated 1,051,787 to 1,480,916 eyes affected annually, with 8-11% of patients having to have the eye removed. Diagnosis requires a corneal scraping, direct microscopy and fungal culture with a large number of airborne fungi implicated. Treatment involves the intensive application of antifungal eye drops, preferably natamycin, often combined with surgery. In low-resource settings, inappropriate corticosteroid eye drops, ineffective antibacterial therapy, diagnostic delay or no diagnosis all contribute to poor ocular outcomes with blindness (unilateral or bilateral) common. Modern detailed guidelines on fungal keratitis diagnosis and management are lacking. Here, we argue that fungal keratitis should be included as a neglected tropical disease, which would facilitate greater awareness of the condition, improved diagnostic capability, and access to affordable antifungal eye medicine.

Indexed as

blindnessfungal keratitisneglected tropical diseases

Identifiers

PMID36294612
PMCPMC9605065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.