ArticleJournal of fungi (Basel, Switzerland)2022
Identification of Dermatophyte and Non-Dermatophyte Agents in Onychomycosis by PCR and DNA Sequencing-A Retrospective Comparison of Diagnostic Tools.
Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Comparative evaluation of conventional and nanopore approaches in onychomycosis diagnosis.Diagnostic microbiology and infectious disease · 2026Article
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- Specific Primers and Nested PCR FindJournal of fungi (Basel, Switzerland) · 2025Article
- Epidemiology and Trends of Cutaneous Fungal Infections (2019-2022) in Israel: A Single Tertiary-Center Study.Journal of fungi (Basel, Switzerland) · 2025Article
- First Report ofJournal of fungi (Basel, Switzerland) · 2025Article
- Dermoscopy-guided sampling improves the diagnostic yield of fungal culture for onychomycosis: a comparative study.Frontiers in medicine · 2025Article
- Monocentric evaluation of the Novaplex dermatophyte multiplex qPCR assay in the diagnosis of dermatophytoses.Journal of clinical microbiology · 2024Article
- Artificial Intelligence in the Diagnosis of Onychomycosis-Literature Review.Journal of fungi (Basel, Switzerland) · 2024Review
- New Diagnostic Strategy for Onychomycosis: First-Line Utilization of DermaGeniusJournal of fungi (Basel, Switzerland) · 2024Article
- Survey on Dermatophytes Isolated from Animals in Switzerland in the Context of the Prevention of Zoonotic Dermatophytosis.Journal of fungi (Basel, Switzerland) · 2023Article
- Detection of Dermatophytes in Subclinically Involved Nails by Polymerase Chain Reaction in Patients with Skin Dermatophytosis: A Prospective Observational Study.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid and reliable fungal identification is crucial to delineate infectious diseases, and to establish appropriate treatment for onychomycosis. Compared to conventional diagnostic methods, molecular techniques are faster and feature higher accuracy in fungal identification. However, in current clinical practice, molecular mycology is not widely available, and its practical applicability is still under discussion. This study summarizes the results of 16,094 consecutive nail specimens with clinical suspicion of onychomycosis. We performed PCR/sequencing on all primary nail specimens for which conventional mycological diagnostics remained inconclusive. In specimens with a positive direct microscopy but negative or contaminated culture, molecular mycology proved superior and specified a fungal agent in 65% (587/898). In 75% (443/587), the identified pathogen was a dermatophyte. Positive cultures for dermatophytes, yeasts and non-dermatophyte molds (NDMs) were concordant with primary-specimen-DNA PCR/sequencing in 83% (10/12), 34% (22/65) and 45% (76/169), respectively. Among NDMs, agreement was high for
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