Evidence map›Paper›PMID 36294550›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Potential Original Drug for Aspergillosis: In Vitro and In Vivo Effects of 1-N,N-Dimethylamino-5-Isocyanonaphthalene (DIMICAN) on

Zsuzsa Máthéné Szigeti, László Tálas, Adrienn Széles, Zoltán Hargitai, Zsolt László Nagy, Miklós Nagy, Alexandra Kiss, Sándor Kéki, Gábor Szemán-Nagy

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zsuzsa Máthéné SzigetiDepartment of Molecular Biotechnology and Microbiology, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.
László TálasDepartment of Molecular Biotechnology and Microbiology, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.
Adrienn SzélesDepartment of Lang Utilisation, Engineering and Precision Farming Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi 138, 4032 Debrecen, Hungary.ORCID 0000-0003-4101-3177
Zoltán HargitaiDepartment of Pathology, Faculty of General Medicine, University of Debrecen, 4031 Debrecen, Hungary.
Zsolt László NagyDepartment of Applied Chemistry, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.
Miklós NagyInstitute of Chemistry, University of Miskolc, Miskolc-Egyetemváros, 3515 Miskolc, Hungary.ORCID 0000-0002-3484-2244
Alexandra KissDepartment of Molecular Biotechnology and Microbiology, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.
Sándor KékiDepartment of Applied Chemistry, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.ORCID 0000-0002-5274-6117
Gábor Szemán-NagyDepartment of Molecular Biotechnology and Microbiology, Faculty of Science, University of Debrecen, 4010 Debrecen, Hungary.
University of Debrecen · HUUniversity of Miskolc · HU

Funding

NFKI K-132685Thematic Excellence Programme TKP2020-IKA-04
6 · The paper itself

Abstract

As the recent outbreak of coronavirus disease 2019 (COVID-19) has shown, viral infections are prone to secondary complications like invasive aspergillosis with a high mortality rate, and therefore the development of novel, effective antifungals is of paramount importance. We have previously demonstrated that 1-amino-5-isocyanonaphthalene (ICAN) derivatives are promising original drug candidates against

Indexed as

antifungal effectAspergillus fumigatusinvasive pulmonary aspergillosis murine modelisocyanide

Identifiers

PMID36294550
PMCPMC9605569
OpenAlexW4296481708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.