ReviewJournal of clinical medicine2022
Risk Factors for Periprosthetic Joint Infection after Primary Total Knee Arthroplasty.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06640491 (Intraosseous Vancomycin and Cefazolin vs Intravenous Administration in Primary Total Knee Arthroplasty), which is not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraosseous Vancomycin and Cefazolin vs Intravenous Administration in Primary Total Knee Arthroplasty
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- A systematic review and meta-analysis comparing outcomes following total knee arthroplasty for rheumatoid arthritis versus for osteoarthritis.BMC musculoskeletal disorders · 2023Pooled it
- Prediction Models for Periprosthetic Joint Infection: A Systematic Review of Traditional and Machine Learning Approaches.Mayo Clinic proceedings. Digital health · 2026Review
- Long-term outcomes of single-radius total knee arthroplasty in an Asian population: a comparison of cruciate-retaining and posterior-stabilized designs.Knee surgery & related research · 2026Article
- Review
- Perioperative risk stratification for periprosthetic joint infection after primary total knee arthroplasty: a case-matched cohort study incorporating serum albumin, glycemic status, and intraoperative hypothermia.Knee surgery & related research · 2026Article
- Low Preoperative Platelet Count Is Associated With Deep Surgical Site Infection in Knee Arthroplasty.Arthroplasty today · 2026Article
- Timing and Trends of Periprosthetic Joint Infections Following Over 1,500,000 Primary and Revision Total Knee and Hip Arthroplasty Cases.Arthroplasty today · 2026Article
- Association of a novel glycemic control index, time in range, with infectious complications after pancreatectomy.Hepatobiliary surgery and nutrition · 2026Article
- Fewer major complications but more pain in reverse shoulder arthroplasty compare with open reduction internal fixation in closed proximal humerus fracture: a National database study.Journal of orthopaedic surgery and research · 2026Article
- Preoperative malnutrition and risk of re-revision and mortality following revision arthroplasty.International journal of surgery (London, England) · 2026Article
- Risk factors and postoperative complications following revision total knee arthroplasty in patients with metabolic syndrome-associated osteoarthritis: a 10-year retrospective analysis using a national inpatient database.Frontiers in endocrinology · 2026Article
- Periprosthetic Joint Infection in Patients with Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis.Hip & pelvis · 2025Review
- Clinical outcomes of intramedullary tibial guides in total knee arthroplasty: experience from a single-centre cohort.Journal of orthopaedic surgery and research · 2025Article
- Heart failure patients demonstrate excellent 1-year outcomes after total knee arthroplasty despite high healthcare utilization.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- DACBiomedicines · 2025Article
- Hidden blood loss in anterior cervical discectomy and fusion with zero-profile anchored spacer for the treatment of cervical radiculopathy.Joint diseases and related surgery · 2025Article
- A Retrospective Cohort Study of Early Prosthetic Joint Infections at a US Academic Medical Center (2014-2023).Cureus · 2025Article
- Impact of intra-articular injection on infection risk and therapeutic effect after unicompartmental knee arthroplasty: a retrospective cohort study.Archives of orthopaedic and trauma surgery · 2025Article
- Balancing form and function: A single-center review of autologous vs. synthetic grafts in cranioplasty.Acta neurochirurgica · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periprosthetic joint infection (PJI) is a major adverse event of primary total knee arthroplasty (TKA) from the patient's perspective, and it is also costly for health care systems. In 2010, the reported incidence of PJI in the first 2 years after TKA was 1.55%, with an incidence of 0.46% between the second and tenth year. In 2022, it has been published that 1.41% of individuals require revision TKA for PJI. The following risk factors have been related to an increased risk of PJI: male sex, younger age, type II diabetes, obesity class II, hypertension, hypoalbuminemia, preoperative nutritional status as indicated by prognostic nutritional index (PNI) and body mass index, rheumatoid arthritis, post-traumatic osteoarthritis, intra-articular injections prior to TKA, previous multi-ligament knee surgery, previous steroid therapy, current tobacco use, procedure type (bilateral), length of stay over 35 days, patellar resurfacing, prolonged operative time, use of blood transfusions, higher glucose variability in the postoperative phase, and discharge to convalescent care. Other reported independent risk factors for PJI (in diminishing order of importance) are congestive heart failure, chronic pulmonary illness, preoperative anemia, depression, renal illness, pulmonary circulation disorders, psychoses, metastatic tumor, peripheral vascular illness, and valvular illness. Preoperative intravenous tranexamic acid has been reported to diminish the risk of delayed PJI. Knowing the risk factors for PJI after TKA, especially those that are avoidable or controllable, is critical to minimizing (ideally preventing) this complication. These risk factors are outlined in this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.