ArticleJournal of clinical medicine2022
Admission Lactate Concentration, Base Excess, and Alactic Base Excess Predict the 28-Day Inward Mortality in Shock Patients.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Combined metabolic risk and admission lactate-to-bicarbonate ratio in critically ill children: a retrospective pediatric ıntensive care cohort study.European journal of pediatrics · 2026Article
- Base deficit and alactic base excess are promising early biological markers in pediatric sepsis.BMC pediatrics · 2026Article
- Acid-Base Status During Venoarterial Extracorporeal Membrane Oxygenator Support in Patients With Cardiogenic Shock.Journal of the American Heart Association · 2026Article
- Association between early arterial pH, base excess and lactate and 24-h mortality and neurological outcomes after cardiac arrest and cardiopulmonary resuscitation: a translational study.Resuscitation plus · 2026Article
- Base Excess and Beyond: Evolving Concepts in Acid-base Analysis.Turkish journal of anaesthesiology and reanimation · 2026Article
- Prognostic value of serial alactic base excess measurements in patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Prognostic Value of Standard Base Excess in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.International journal of nephrology · 2026Article
- Predictive performance of central venous oxygen saturation, lactate, base excess, and alactic base excess for intradialytic hypotension.BMC nephrology · 2025Observational
- Insights Into the Pathophysiology of Catecholamine-Refractory Shock: A Narrative Review.Cureus · 2025Review
- Association between alactic base excess on mortality in sepsis patients: a retrospective observational study.Journal of intensive care · 2025Article
- Prognostic accuracy of oxygen debt for mortality in patients undergoing venoarterial extracorporeal membrane oxygenation therapy: a retrospective cohort study.Frontiers in medicine · 2025Article
- Alactic base excess is not a sensitive or specific diagnostic tool for outcome in horses with colic.Frontiers in veterinary science · 2025Article
- Investigation of Lactate, Base Excess, and Alactic Base Excess in Patients With Upper Gastrointestinal Bleeding.Emergency medicine international · 2025Article
- Electrocardiographic Changes, Mortality, and Late Period Findings in Methyl Alcohol Poisoning.Journal of clinical medicine · 2024Article
- Association of alactic base excess with in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms.Journal of clinical medicine · 2024Article
- The 6-hour lactate clearance rate in predicting 30-day mortality in cardiogenic shock.Journal of intensive medicine · 2024Article
- Base excess (BE): reloaded.European journal of medical research · 2024Review
- Prognostic Impact of Alactic Base Excess in Critically Ill Patients with Sepsis-Associated Disseminated Intravascular Coagulation: A Retrospective Observational Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisObservational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Base excess (BE) and lactate concentration may predict mortality in critically ill patients. However, the predictive values of alactic BE (aBE; the sum of BE and lactate), or a combination of BE and lactate are unknown. The study aimed to investigate whether BE, lactate, and aBE measured on admission to ICU may predict the 28-day mortality for patients undergoing any form of shock. In 143 consecutive adults, arterial BE, lactate, and aBE were measured upon ICU admission. Receiver Operating Curve (ROC) characteristics and Cox proportional hazard regression models (adjusted to age, gender, forms of shock, and presence of severe renal failure) were then used to investigate any association between these parameters and 28-day mortality. aBE < −3.63 mmol/L was found to be associated with a hazard ratio of 3.19 (HR; 95% confidence interval (CI): 1.62−6.27) for mortality. Risk of death was higher for BE < −9.5 mmol/L (HR: 4.22; 95% CI: 2.21−8.05), particularly at lactate concentrations > 4.5 mmol/L (HR: 4.62; 95% CI: 2.56−8.33). A 15.71% mortality rate was found for the combined condition of BE > cut-off and lactate < cut-off. When BE was below but lactate above their respective cut-offs, the mortality rate increased to 78.91%. The Cox regression model demonstrated that the predictive values of BE and lactate were mutually independent and additive. The 28-day mortality in shock patients admitted to ICU can be predicted by aBE, but BE and lactate deliver greater prognostic value, particularly when combined. The clinical value of our findings deserves further prospective evaluation.
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