Evidence map›Paper›PMID 36294334›Full record

ReviewJournal of clinical medicine2022

Osteoarthritis: New Insight on Its Pathophysiology.

Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli, Giustino Varrassi

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 157 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 4 pooled it
32.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06404606 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis.

TypeinterventionalSponsorPakistan Society for Rehabilitation of Differently Abled HospitalRan2024 to 2025Enrolled30ConditionsOsteoarthritisArmsBlack cumin and turmeric with Quantum Acoustic Waves (QAW)
NCT07642258 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Sahrmann's Approach Versus Conventional Treatment on Pain, Valgus Angle and Functional Disability in Patients With Knee Osteoarthritis

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled40ConditionsKnee OsteoarthritisArmsSahrmann's exercises, standard physical therapy treatment
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 4 syntheses or guidelines pooled it, 218 citations in OpenAlex.

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  4. Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Stefano CoaccioliEuropean League Against Pain, 8000 Zurich, Switzerland.
Piercarlo Sarzi-PuttiniMilano University, 20090 Milano, Italy.
Panagiotis ZisAttikon University Hospital, National & Kapodistrian University, 157 72 Athens, Greece.
Giuseppe RinonapoliPerugia University, 06126 Perugia, Italy.
Giustino VarrassiPaolo Procacci Foundation, 00193 Rome, Italy.
European League Against Rheumatism · CHFondazione Roma · ITNational and Kapodistrian University of Athens · GRUniversity of Milan · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in recent years. It has been observed that cartilage degeneration is preceded by subchondral bone lesions, suggesting a key role of this mechanism within the pathogenesis and progression of OA, as well as the formation of ectopic bone and osteophytes. Moreover, low-grade, chronic inflammation of the synovial lining has gained a central role in the definition of OA physiopathology, and central immunological mechanisms, innate but also adaptive, are now considered crucial in driving inflammation and tissue destruction. In addition, the role of neuroinflammation and central sensitization mechanisms as underlying causes of pain chronicity has been characterized. This has led to a renewed definition of OA, which is now intended as a complex multifactorial joint pathology caused by inflammatory and metabolic factors underlying joint damage. Since this evidence can directly affect the definition of the correct therapeutic approach to OA, an improved understanding of these pathophysiological mechanisms is fundamental. To this aim, this review provides an overview of the most updated evidence on OA pathogenesis; it presents the most recent insights on the pathophysiology of OA, describing the interplay between immunological and biochemical mechanisms proposed to drive inflammation and tissue destruction, as well as central sensitization mechanisms. Moreover, although the therapeutic implications consequent to the renewed definition of OA are beyond this review scope, some suggestions for intervention have been addressed.

Indexed as

inflammationosteoarthritisphysiopathologysubchondral bonesynovium

Identifiers

PMID36294334
PMCPMC9604603
OpenAlexW4304806793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.