ArticleInternational journal of environmental research and public health2022
Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiac MRI after Sudden Cardiac Arrest: A Systematic Review.Radiology. Cardiothoracic imaging · 2024Pooled it
- Redefining the Post-Mortem Investigation of Sudden Cardiac Death: Systematic Cardiac MR with Macroscopic and Histological Correlation from the Friuli Venezia Giulia Regional Registry.Diagnostics (Basel, Switzerland) · 2026Article
- Standardized processing of explanted hearts after stereotactic arrhythmia radiotherapy (Bio-STAR): a STOPSTORM framework and first human findings.European heart journal open · 2026Article
- Post-mortem ultrasound study of coronary circulation on ex-situ hearts.International journal of legal medicine · 2026Article
- Lipidomic Profiling of Hyperacute Ischemic Heart Disease and Toxic Deaths: A Forensic Investigation into Metabolic Biomarkers.International journal of molecular sciences · 2025Article
- Clinical autopsy: methodological applications and scientific perspectives in post-mortem diagnostics.Pathologica · 2025Article
- Post-mortem Cardiac MRI in Sudden Cardiac Death: The Interesting Intertwining of Radiology and Histology to Diagnose Arrhythmic Death or Myocardial Infarction.Current medical imaging · 2025Article
- Unveiling the spectrum of sudden cardiac death: a multidisciplinary analysis from the Friuli Venezia Giulia registry.Frontiers in cardiovascular medicine · 2025Article
- Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology.Frontiers in cardiovascular medicine · 2025Review
- Postmortem magnetic resonance imaging findings of tricuspid atresia with ventricular and atrial septal defects and subvalvular pulmonic stenosis in a Japanese native Noma horse.Journal of equine science · 2023Article
- Pregnancy-Associated Spontaneous Coronary Acute Dissection as a Cause of Sudden Cardiac Death-Autopsy Findings and Literature Review: Is COVID-19 Related?Medicina (Kaunas, Lithuania) · 2023Review
- Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Correction: Aquaro et al. Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death.International journal of environmental research and public health · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to evaluate the diagnostic accuracy of post-mortem cardiac magnetic resonance (PMCMR) of explanted hearts to detect the cardiac causes of sudden death.
methodsPMCMR was performed in formalin-fixed explanted hearts of 115 cases of sudden death. Histological sampling of myocardium was performed using two different approaches: (1) guideline-based sampling; (2) guideline-based plus PMCMR-driven sampling.
resultsForensic diagnosis of cardiac cause of death was ascertained in 72 (63%) patients. When the guideline-driven histological sampling was used, the PMCMR interpretation matched with final forensic diagnosis in 93 out of 115 cases (81%) with sensitivity of 88% (79-95%), specificity of 65% (47-80%), PPV of 84% (78-90%), NPV of 73% (58-84%), accuracy of 81% (72-88%), and AUC of 0.77 (0.68-0.84). When a PMCMR-driven approach was added to the guideline-based one, the matching increased to 102 (89%) cases with a PMCMR sensitivity of 89% (80-94%), a specificity of 86% (67-96%), PPV of 95% (89-98%), NPV of 73% (59-83%), accuracy of 89% (81-93%), and AUC of 0.88 (0.80-0.93).
conclusionsPMCMR has high accuracy to identify the cardiac cause of sudden death and may be considered a valid auxilium for forensic diagnosis. PMCMR could improve histological diagnosis in conditions with focal myocardial involvement or demonstrating signs of myocardial ischemia.
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