Evidence map›Paper›PMID 36293881›Full record

ArticleInternational journal of environmental research and public health2022

Virtual Reality and Exercise Training Enhance Brain, Cognitive, and Physical Health in Older Adults with Mild Cognitive Impairment.

Ja-Gyeong Yang, Ngeemasara Thapa, Hye-Jin Park, Seongryu Bae, Kyung Won Park, Jong-Hwan Park, Hyuntae Park

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07722169 (Home-based Virtual Reality Cognitive Training as an add-on to Telerehabilitation in Alzheimer's Disease), which is not on this map. Cited by 35 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 10 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07722169 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Home-based Virtual Reality Cognitive Training as an add-on to Telerehabilitation in Alzheimer's Disease: Validation of a Protocol to Slow Down Cognitive Decline and Reduce Caregivers' Burden

TypeinterventionalSponsorIRCCS San RaffaeleRan2026 to 2029Enrolled48ConditionsAlzheimerArmsOnline cognitive telerehabilitation, VRRS tablet
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 10 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ja-Gyeong YangDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea.
Ngeemasara ThapaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea.ORCID 0000-0001-9394-2539
Hye-Jin ParkDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea.
Seongryu BaeDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea.
Kyung Won ParkDepartment of Neurology, College of Medicine, Dong-A University, Busan 49201, Korea.ORCID 0000-0002-6788-5267
Jong-Hwan ParkHealth Convergence Medicine Laboratory, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.ORCID 0000-0003-2815-7248
Hyuntae ParkDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea.ORCID 0000-0002-1976-0005
Dong-A University · KRPusan National University Hospital · KR

Funding

Ministry of Education of the Republic of Korea and the National Re-search Foundation of Korea NRF-2017S1A5A8021740
6 · The paper itself

Abstract

We investigated the effectiveness of virtual-reality-based cognitive training (VRCT) and exercise on the brain, cognitive, physical and activity of older adults with mild cognitive impairment (MCI).

methodsThis study included 99 participants (70.8 ± 5.4) with MCI in the VRCT, exercise, and control groups. The VRCT consisted of a series of games targeting different brain functions such as executive function, memory, and attention. Twenty-four sessions of VRCT (three days/week) were performed, and each session was 100 min long. Exercise intervention consisted of aerobic and resistance trainings performed in 24 sessions for 60 min (2 times/week for 12 weeks). Global cognitive function was measured using the Mini-Mental State Examination (MMSE) test. Resting-state electroencephalography (EEG) of the neural oscillatory activity in different frequency bands was performed. Physical function was measured using handgrip strength (HGS) and gait speed.

resultsAfter the intervention period, VRCT significantly improved the MMSE scores (

conclusionOur findings suggest that VRCT and exercise training enhances brain, cognitive, and physical health in older adults with MCI. Further studies with a larger population sample to identify the effect of VRCT in combination with exercise training are required to yield peak benefits for patients with MCI.

Indexed as

Cognitive DysfunctionVirtual RealityAgedBrainCognitionExerciseHand StrengthHumansNeuropsychological Testscognitionelectroencephalogramexercisemild cognitive impairmentvirtual reality

Identifiers

PMID36293881
PMCPMC9602597
OpenAlexW4306381994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.