Evidence map›Paper›PMID 36293620›Full record

ArticleInternational journal of environmental research and public health2022

The Influence of Parental Environmental Exposure and Nutrient Restriction on the Early Life of Offspring Growth in Gambia-A Pilot Study.

Ousman Bajinka, Amadou Barrow, Sang Mendy, Binta J J Jallow, Jarry Jallow, Sulayman Barrow, Ousman Bah, Saikou Camara, Modou Lamin Colley, Sankung Nyabally and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ousman BajinkaDepartment of Medical Microbiology, Central South University, Changsha 410078, China.ORCID 0000-0002-2871-4078
Amadou BarrowSchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.ORCID 0000-0002-6006-9355
Sang MendyMinistry of Health, Banjul P.O. Box 273, The Gambia.
Binta J J JallowDepartment of Medical Microbiology, Central South University, Changsha 410078, China.ORCID 0000-0001-6753-9957
Jarry JallowSchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.
Sulayman BarrowSchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.
Ousman BahMinistry of Health, Banjul P.O. Box 273, The Gambia.
Saikou CamaraSchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.
Modou Lamin ColleySchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.
Sankung NyaballySchool of Medicine and Allied Health Sciences, University of The Gambia, Kanifing 3530, The Gambia.
Amie N JoofDepartment of Medical Microbiology, Central South University, Changsha 410078, China.
Mingming QiDepartment of Obstetrics, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Changsha 410017, China.
Yurong TanDepartment of Medical Microbiology, Central South University, Changsha 410078, China.ORCID 0000-0002-0283-2105
University of the Gambia · GMCentral South University · CNMinistry of Health and Social Welfare · GM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of the germline in epigenetic transgenerational inheritance starts with environmental factors, acting on the first generation of a gestating mother. These factors influence the developing second-generation fetus by altering gonadal development, thereby reprogramming the primordial germ cell DNA methylation and leading to consequences that might be seen along generations.

objectiveDespite these epigenetic factors now surfacing, the few available studies are on animal-based experiments, and conducting a follow-up on human intergenerational trials might take decades. To this response, this study aimed to determine the influence of parental energy, toxicant exposure, age, and nutrient restriction on the early life of offspring growth in Gambia.

methodThis pilot study was based on population observation and combined both maternal and paternal factors across the country between August and October 2021. It captures the lifestyle and health detailed account of 339 reproductive parents and their last born (child under 5 years) using a structured interview questionnaire performed by nurses and public health officers.

resultsThis study showed that parents who worked in industrial areas were more likely to have offspring with poor psychosocial skills. In addition, mothers who are exposed to oxidative stress and high temperatures are more likely to have offspring with poor psychosocial skills. Mothers who consume a high-protein diet were almost three times more likely to have infants with good psychosocial skills in their offspring. Furthermore, there was a negative correlation between maternal stress during pregnancy and the psychosocial skills of offspring.

conclusionThis study was able to ascertain if the maternal diet during gestation, toxicant exposure, maternal stress, and parental smoking habits have an influence on the early life of offspring. While the study recommends a large sample size study to eliminate selection bias, there should be an increased level of awareness of mothers of their offspring's health and their husbands' lifestyles that might influence the adulthood health of their offspring.

Indexed as

DNA MethylationNutrientsAdultAnimalsChildEnvironmental ExposureFemaleGambiaHumansInfantPilot ProjectsPregnancyNutrientsepigeneticsmaternal stressoffspring healthparental smokingtoxicant exposure

Identifiers

PMID36293620
PMCPMC9603272
OpenAlexW4304587289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.