Evidence map›Paper›PMID 36293528›Full record

ReviewInternational journal of molecular sciences2022

Lipopolysaccharides (LPSs) as Potent Neurotoxic Glycolipids in Alzheimer's Disease (AD).

Yuhai Zhao, Vivian R Jaber, Aileen I Pogue, Nathan M Sharfman, Christopher Taylor, Walter J Lukiw

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  3. The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuhai ZhaoLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Vivian R JaberLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Aileen I PogueAlchem Biotech Research, Toronto, ON M5S 1A8, Canada.
Nathan M SharfmanLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Christopher TaylorDepartment of Microbiology, Immunology & Parasitology, LSU Health Science Center, New Orleans, LA 70112, USA.
Walter J LukiwLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Louisiana State University Health Sciences Center New Orleans · US

Funding

OCULAR HSV: LATENCY, REACTIVATION, &RECURRENCER01EY006311 · NEI · LSU HEALTH SCIENCES CENTER · PI HILL, JAMES M · 1985 to 2012
$5.3M
microRNA (miRNA) signaling in Alzheimer's disease(AD)R01AG038834 · NIA · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G. · 2011 to 2020
$3.3M
Gene Expression in Alzheimer's DiseaseR01AG018031 · NIA · LSU HEALTH SCIENCES CENTER · PI LUKIW, WALTER J · 2001 to 2006
$1.4M
Joe W. and Dorothy Dorsett Brown Foundation 2021-2022NEI NIH HHS R01 EY006311NIA NIH HHS R01 AG018031NIA NIH HHS R01 AG038834NIH HHS AG038834NIH HHS AG18031Research to Prevent Blindness LSU Ophthalmology
6 · The paper itself

Abstract

Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most potent pro-inflammatory neurotoxins known. In

Indexed as

Alzheimer DiseaseMicroRNAsNeurodegenerative DiseasesNeurotoxicity SyndromesAgedGlycolipidsHumansLipopolysaccharidesNeurotoxinsNF-kappa BRNA, MessengerGlycolipidsLipopolysaccharidesMicroRNAsMIRN155 microRNA, humanNeurotoxinsNF-kappa BRNA, MessengerAlzheimer’s disease (AD)dysbiosisgastrointestinal tractlipopolysaccharide (LPS)microbiomemiRNA-146amiRNA-155miRNA-30neurofilament light (NF-L)neuronal atrophyNF-kB (p50/p65)synaptic disorganization

Identifiers

PMID36293528
PMCPMC9604166
OpenAlexW4307273319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.