Evidence map›Paper›PMID 36293516›Full record

ArticleInternational journal of molecular sciences2022

Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice.

Lianwei Mu, Dongdong Xia, Jiajia Cai, Boya Gu, Xiaojie Liu, Vladislav Friedman, Qing-Song Liu, Li Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Effects of physical exercise on cognitive impairment in patients with Alzheimer's disease, Parkinson's disease or mild cognitive impairment: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lianwei MuDepartment of Exercise Physiology, Guangzhou Sport University, Guangzhou 510500, China.
Dongdong XiaKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
Jiajia CaiKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
Boya GuKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
Xiaojie LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.ORCID 0000-0001-9843-1674
Vladislav FriedmanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.ORCID 0000-0002-5567-2520
Qing-Song LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.ORCID 0000-0003-1858-1504
Li ZhaoKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
Beijing Sport University · CNMedical College of Wisconsin · US

Funding

Circuit-specific actions of endocannabinoids in stress and mood disordersR01MH121454 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J, LIU, QING-SONG · 2019 to 2023
$1.9M
Zona Incerta Contributions to Reward and Cocaine AddictionR01DA047269 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI LIU, QING-SONG · 2019 to 2023
$1.8M
NIDA NIH HHS R01 DA047269NIMH NIH HHS R01 MH121454
6 · The paper itself

Abstract

Physical exercise improves memory and cognition in physiological aging and Alzheimer's disease (AD), but the mechanisms remain poorly understood. Here, we test the hypothesis that Aβ oligomer accumulation, neuroinflammation, and glial cell activation may lead to disruption of synaptic transmission in the prefrontal cortex of 3 × Tg-AD Mice, resulting in impairment of learning and memory. On the other hand, treadmill exercise could prevent the pathogenesis and exert neuroprotective effects. Here, we used immunohistochemistry, western blotting, enzyme-linked immunosorbent assay, and slice electrophysiology to analyze the levels of GSK3β, Aβ oligomers (Aβ dimers and trimers), pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), the phosphorylation of CRMP2 at Thr514, and synaptic currents in pyramidal neurons in the prefrontal cortex. We show that 12-week treadmill exercise beginning in three-month-old mice led to the inhibition of GSK3β kinase activity, decreases in the levels of Aβ oligomers, pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), and the phosphorylation of CRMP2 at Thr514, reduction of microglial and astrocyte activation, and improvement of excitatory and inhibitory synaptic transmission of pyramidal neurons in the prefrontal cortex of 3 × Tg-AD Mice. Thus, treadmill exercise reduces neuroinflammation, glial cell activation and improves synaptic transmission in the prefrontal cortex in 3 × Tg-AD mice, possibly related to the inhibition of GSK3β kinase activity.

Indexed as

Alzheimer DiseaseNeuroprotective AgentsAmyloid beta-PeptidesAnimalsDisease Models, AnimalGlycogen Synthase Kinase 3 betaInterleukin-6MiceMice, TransgenicMicrogliaNeuroinflammatory DiseasesPrefrontal CortexSynaptic TransmissionTumor Necrosis Factor-alphaAmyloid beta-PeptidesGlycogen Synthase Kinase 3 betaInterleukin-6Neuroprotective AgentsTumor Necrosis Factor-alpha3 × Tg-AD miceAβ oligomerexerciseglial cellGSK3βinflammatory factorsynaptic plasticity

Identifiers

PMID36293516
PMCPMC9604030
OpenAlexW4307160336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.