Evidence map›Paper›PMID 36293503›Full record

ArticleInternational journal of molecular sciences2022

Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion.

Bianca Cruz Pachane, Ana Carolina Caetano Nunes, Thais Regiani Cataldi, Kelli Cristina Micocci, Bianca Caruso Moreira, Carlos Alberto Labate, Heloisa Sobreiro Selistre-de-Araujo, Wanessa Fernanda Altei

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

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  13. Breaking free: endocytosis and endosomal escape of extracellular vesicles.Extracellular vesicles and circulating nucleic acids · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Bianca Cruz PachaneBiochemistry and Molecular Biology Laboratory, Department of Physiological Sciences, Universidade Federal de São Carlos-UFSCar, São Carlos 13565-905, SP, Brazil.ORCID 0000-0002-7302-4498
Ana Carolina Caetano NunesBiochemistry and Molecular Biology Laboratory, Department of Physiological Sciences, Universidade Federal de São Carlos-UFSCar, São Carlos 13565-905, SP, Brazil.ORCID 0000-0002-8213-2159
Thais Regiani CataldiMax Feffer Plant Genetics Laboratory, Department of Genetics, University of São Paulo-ESALQ, Piracicaba 13418-900, SP, Brazil.ORCID 0000-0002-9827-2017
Kelli Cristina MicocciCenter for the Study of Social Insects, São Paulo State University "Julio de Mesquita Filho", Rio Claro 14884-900, SP, Brazil.
Bianca Caruso MoreiraBiochemistry and Molecular Biology Laboratory, Department of Physiological Sciences, Universidade Federal de São Carlos-UFSCar, São Carlos 13565-905, SP, Brazil.ORCID 0000-0002-8694-885X
Carlos Alberto LabateMax Feffer Plant Genetics Laboratory, Department of Genetics, University of São Paulo-ESALQ, Piracicaba 13418-900, SP, Brazil.
Heloisa Sobreiro Selistre-de-AraujoBiochemistry and Molecular Biology Laboratory, Department of Physiological Sciences, Universidade Federal de São Carlos-UFSCar, São Carlos 13565-905, SP, Brazil.
Wanessa Fernanda AlteiMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-6636-7951
Universidade Federal de São Carlos · BRUniversidade de São Paulo · BRHospital de Câncer de Barretos · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001National Council for Scientific and Technological Development 429235/2018-6São Paulo Research Foundation 2017/06198-8São Paulo Research Foundation 2019/05149-9São Paulo Research Foundation 2019/11437-7São Paulo Research Foundation 2019/17737-2São Paulo Research Foundation 2021/01983-4
6 · The paper itself

Abstract

Hypoxia, a condition of low oxygenation frequently found in triple-negative breast tumors (TNBC), promotes extracellular vesicle (EV) secretion and favors cell invasion, a complex process in which cell morphology is altered, dynamic focal adhesion spots are created, and ECM is remodeled. Here, we investigated the invasive properties triggered by TNBC-derived hypoxic small EV (SEVh) in vitro in cells cultured under hypoxic (1% O

Indexed as

Extracellular VesiclesTriple Negative Breast NeoplasmsCell Line, TumorCell ProliferationGelatinasesHumansHypoxiaIntegrinsMetalloproteasesOxygenProteomeProteomicsGelatinasesIntegrinsMetalloproteasesOxygenProteomebreast cancercell invasionextracellular vesicleshypoxia

Identifiers

PMID36293503
PMCPMC9604480
OpenAlexW4307273083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.