Evidence map›Paper›PMID 36293483›Full record

ArticleInternational journal of molecular sciences2022

Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.

Hongfei Liu, Jiankun Liu, Changkun Long, Liping Chen, Wenxing Zhan, Wanli Xiao, Xueting Gong, Man Liu, Xiao-Li Tian, Shenghan Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Nuclear m6A Methylase METTL3 Drives Production of ITGβ4E to Exacerbate Heart Failure via SRSF3-Mediated Alternative Splicing of ITGβ4.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hongfei LiuVascular Function Laboratory, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0003-4335-0652
Jiankun LiuAging and Vascular Diseases, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Changkun LongVascular Function Laboratory, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-6474-7627
Liping ChenVascular Function Laboratory, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Wenxing ZhanVascular Function Laboratory, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Wanli XiaoMetabolic Control and Aging, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Xueting GongAging and Vascular Diseases, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Man LiuAging and Vascular Diseases, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Xiao-Li TianAging and Vascular Diseases, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-0868-7025
Shenghan ChenVascular Function Laboratory, Human Aging Research Institute, School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-6521-7791
Nanchang University · CN

Funding

Key Program of the Jiangxi Province, China 20181BCD40001National Key Research and Development Program of China 2020YFC2002900National Natural Science Foundation of China 81771514National Natural Science Foundation of China 82071592
6 · The paper itself

Abstract

Natriuretic peptide receptor 1 (NPR1) serves as a modulator of vascular endothelial homeostasis. Interactions between monocytes and endothelial cells may initiate endothelium dysfunction, which is known as an early hallmark of atherosclerosis. In this study, we performed RNA-sequencing analysis for the aorta of

Indexed as

AtherosclerosisIntercellular Adhesion Molecule-1AnimalsCell AdhesionEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsIntegrinsMiceMonocytesReceptors, Atrial Natriuretic FactorRNATumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1atrial natriuretic factor receptor AIntegrinsIntercellular Adhesion Molecule-1Receptors, Atrial Natriuretic FactorRNATumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1cell adhesionendothelial cellsintegrin beta 4NPR1

Identifiers

PMID36293483
PMCPMC9604115
OpenAlexW4306920597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.