Evidence map›Paper›PMID 36293430›Full record

ReviewInternational journal of molecular sciences2022

Relationships between Inflammation and Age-Related Neurocognitive Changes.

Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
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  13. The Hallmarks of Ageing in Microglia.Cellular and molecular neurobiology · 2025
    Review
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  16. Article
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  18. Aging shapes baseline immunity in sterile-housed female hAPOE mouse genotypes.Journal of cellular and molecular immunology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Run JinState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China.
Aidan Kai Yeung ChanState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China.
Jingsong WuCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.
Tatia Mei Chun LeeState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China.
University of Hong Kong · HKChinese University of Hong Kong · CNFujian University of Traditional Chinese Medicine · CN

Funding

Hong Kong Research Grant Council General Research Fund 17600621The University of Hong Kong May Endowed Professorship in Neuropsychology NA
6 · The paper itself

Abstract

The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this review, we discuss the potential mechanisms, including the development of vascular inflammation, neuroinflammation, organelle dysfunctions, abnormal cholesterol metabolism, and glymphatic dysfunctions as well as the role that the key molecules play in the immune-cognition interplay. We propose potential therapeutic pharmacological and behavioral strategies for ameliorating age-related neurocognitive changes associated with inflammation. Further research to decipher the multidimensional roles of chronic inflammation in normal and pathological aging processes will help unfold the pathophysiological mechanisms underpinning neurocognitive disorders. The insight gained will lay the path for developing cost-effective preventative measures and the buffering or delaying of age-related neurocognitive decline.

Indexed as

InflammationNeurocognitive DisordersAgingCentral Nervous SystemCognitionHumansagingbraincognitioninflammationneurodegeneration

Identifiers

PMID36293430
PMCPMC9604276
OpenAlexW4306925998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.