Evidence map›Paper›PMID 36293361›Full record

ArticleInternational journal of molecular sciences2022

The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients.

Burook Misganaw, Ruoting Yang, Aarti Gautam, Seid Muhie, Synthia H Mellon, Owen M Wolkowitz, Kerry J Ressler, Francis J Doyle, Charles R Marmar, Marti Jett and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Burook MisganawMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Ruoting YangMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Aarti GautamMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Seid MuhieMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Synthia H MellonDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA.
Owen M WolkowitzDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143, USA.
Kerry J ResslerMcLean Hospital, Belmont, MA 02478, USA.
Francis J DoyleHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.ORCID 0000-0002-3293-9114
Charles R MarmarDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Marti JettMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-2899-0216
Rasha HammamiehMedical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Funding

United States Department of Defense W911NF-13-1-0376, W911NF-17-2-0086, W911NF-18-2-0056, W911NF-17-1-0069, W81XWH-10-1-0021, W81XWH09-2-0044, W81XWH-14-1-0043, W81XWH-10-2-0072 and W81XWH-13-1-0071
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a highly debilitating psychiatric disorder that can be triggered by exposure to extreme trauma. Even if PTSD is primarily a psychiatric condition, it is also characterized by adverse somatic comorbidities. One illness commonly co-occurring with PTSD is Metabolic syndrome (MetS), which is defined by a set of health risk/resilience factors including obesity, elevated blood pressure, lower high-density lipoprotein cholesterol, higher low-density lipoprotein cholesterol, higher triglycerides, higher fasting blood glucose and insulin resistance. Here, phenotypic association between PTSD and components of MetS are tested on a military veteran cohort comprising chronic PTSD presentation (

Indexed as

Metabolic SyndromeStress Disorders, Post-TraumaticBlood GlucoseCholesterolFemaleHumansLipoproteins, HDLLipoproteins, LDLMaleObesityPrevalenceTriglyceridesBlood GlucoseCholesterolLipoproteins, HDLLipoproteins, LDLTriglyceridesgenetic correlationMDD (major depressive disorder)metabolic syndromeobesityPTSD (post-traumatic stress disorder)

Identifiers

PMID36293361
PMCPMC9604263

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.