ArticleInternational journal of molecular sciences2022
The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Shielding assessment for multi-ion radiotherapy based on ion-specific dose-defined workloads.Scientific reports · 2026Article
- Comparative evaluation of the Mayo Clinic Florida microdosimetric kinetic model and mMKM for carbon ion treatment planning: A matRad-based analysis.Journal of applied clinical medical physics · 2026Article
- Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector.Medical physics · 2025Article
- Quantifying Sensitivity of Carbon RBE Models to Reference Parameter Variations.Radiation research · 2025Article
- Review
- Variation of the relative biological effectiveness in the penumbra of ion therapy beams estimated using different microdosimetric approaches.Physics and imaging in radiation oncology · 2024Article
- A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- A methodology to abridge microdosimetric distributions without a significant loss of the spectral information needed for the RBE computation in carbon ion therapy.Journal of applied clinical medical physics · 2023Article
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Authors and funding
3 authors.
Funding
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Abstract
The relative biological effectiveness (RBE) calculations used during the planning of ion therapy treatments are generally based on the microdosimetric kinetic model (MKM) and the local effect model (LEM). The Mayo Clinic Florida MKM (MCF MKM) was recently developed to overcome the limitations of previous MKMs in reproducing the biological data and to eliminate the need for ion-exposed in vitro data as input for the model calculations. Since we are considering to implement the MCF MKM in clinic, this article presents (a) an extensive benchmark of the MCF MKM predictions against corresponding in vitro clonogenic survival data for 4 rodent and 10 cell lines exposed to ions from
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