Evidence map›Paper›PMID 36293318›Full record

ArticleInternational journal of molecular sciences2022

Genomic Basis for Individual Differences in Susceptibility to the Neurotoxic Effects of Diesel Exhaust.

Alexandra Noël, David G Ashbrook, Fuyi Xu, Stephania A Cormier, Lu Lu, James P O'Callaghan, Shyam K Menon, Wenyuan Zhao, Arthur L Penn, Byron C Jones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Alexandra NoëlDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
David G AshbrookDepartment of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7397-8910
Fuyi XuDepartment of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Stephania A CormierDepartment of Biological Sciences, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.ORCID 0000-0002-6050-6172
Lu LuDepartment of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
James P O'CallaghanMolecular Neurotoxicology Laboratory, Toxicology, and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, NIOSH, Morgantown, WV 26508, USA.
Shyam K MenonDepartment of Mechanical and Industrial Engineering, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Wenyuan ZhaoDepartment of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Arthur L PennDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Byron C JonesDepartment of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
University of Tennessee Health Science Center · USLouisiana State University · USBinzhou Medical University · CNCenters for Disease Control and Prevention · USPennington Biomedical Research Center · US

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI LOMNICKI, SLAWO M · 2009 to 2024
$27.6M
DNA methylation differences between identical twinsR01ES015150 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, THOMAS MCCULLOCH · 2006 to 2009
$3.1M
Neural Toxicity of Paraquat is Related to Iron Regulation in the MidbrainR01ES022614 · NIEHS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JONES, BYRON C, LU, LU · 2014 to 2018
$2.8M
Louisiana Governor's Biotechnology Initiative GBI-BOR#13NIEHS NIH HHS P42 ES013648NIEHS NIH HHS R01 ES015150NIEHS NIH HHS R01 ES022614United States Public Health Service ES013648United States Public Health Service ES015150United States Public Health Service ES022614
6 · The paper itself

Abstract

Air pollution is a known environmental health hazard. A major source of air pollution includes diesel exhaust (DE). Initially, research on DE focused on respiratory morbidities; however, more recently, exposures to DE have been associated with neurological developmental disorders and neurodegeneration. In this study, we investigated the effects of sub-chronic inhalation exposure to DE on neuroinflammatory markers in two inbred mouse strains and both sexes, including whole transcriptome examination of the medial prefrontal cortex. We exposed aged male and female C57BL/6J (B6) and DBA/2J (D2) mice to DE, which was cooled and diluted with HEPA-filtered compressed air for 2 h per day, 5 days a week, for 4 weeks. Control animals were exposed to HEPA-filtered air on the same schedule as DE-exposed animals. The prefrontal cortex was harvested and analyzed for proinflammatory cytokine gene expression (

Indexed as

Air PollutantsNeurotoxicity SyndromesAnimalsCytokinesFemaleGenomicsIndividualityInhalation ExposureInterleukin-6MaleMiceMice, Inbred C57BLMice, Inbred DBATumor Necrosis Factor-alphaVehicle EmissionsAir PollutantsCytokinesInterleukin-6Tumor Necrosis Factor-alphaVehicle Emissionsdiesel exhaustenvironmentally persistent free radicalsneuroinflammationneurotoxicitypollutionsexstrain

Identifiers

PMID36293318
PMCPMC9603950
OpenAlexW4306742432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.