ArticleInternational journal of molecular sciences2022
Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation.
Theresa Aliwarga, Jean C Dinh, Scott Heyward, Bhagwat Prasad, Sina A Gharib, Rozenn N Lemaitre, Nona Sotoodehnia, Rheem A Totah
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 3 institutions in 2 countries.
Theresa AliwargaDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-0339-9948 Jean C DinhCertara/SimCYP Ltd., Sheffield S1 2BJ, UK.
Scott HeywardBioIVT, Baltimore, MD 21227, USA.
Bhagwat PrasadDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Sina A GharibComputational Medicinal Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA 98104, USA.ORCID 0000-0002-2480-4367 Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.ORCID 0000-0002-7038-1844 Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Rheem A TotahDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
University of Washington · USSimcyp (United Kingdom) · GBWashington State University Spokane · US
Funding
GENOMICS OF SUDDEN CARDIAC ARRESTR01HL088456 · NHLBI · UNIVERSITY OF WASHINGTON · PI SOTOODEHNIA, NONA · 2007 to 2011
$3.2MCYP2J2 Mediated Eicosanoids in Arrhythmias and Sudden Cardiac ArrestR01HL128709 · NHLBI · UNIVERSITY OF WASHINGTON · PI SOTOODEHNIA, NONA, TOTAH, RHEEM ANGELA · 2015 to 2018
$2.9MEpoxyeicosatrienoic acids, diabetes, and cardiovascular diseaseR01HL130880 · NHLBI · UNIVERSITY OF WASHINGTON · PI LEMAITRE, ROZENN, TOTAH, RHEEM ANGELA · 2016 to 2019
$2.8MNational Heart Lung and Blood Institute R01HL088456National Heart Lung and Blood Institute R01HL096706National Heart Lung and Blood Institute R01HL130880NHLBI NIH HHS R01 HL088456NHLBI NIH HHS R01 HL128709NHLBI NIH HHS R01 HL130880
6 · The paper itselfAbstract
CYP2J2 is the main epoxygenase in the heart that is responsible for oxidizing arachidonic acid to
Indexed as
Cardiovascular DiseasesHeart DiseasesArachidonic AcidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEicosanoidsEpoxide HydrolasesHumansNADPTerfenadineArachidonic AcidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEicosanoidsEpoxide HydrolasesNADPTerfenadinearachidonic acidcardiac tissuecis-EETCVDCYP2J2Cytochrome P450EETsEPHX2PORproteomicstrans-EET
Identifiers
PMID36293289
PMCPMC9604309
OpenAlexW4306658536
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390