Evidence map›Paper›PMID 36293208›Full record

ArticleInternational journal of molecular sciences2022

Analyses of circRNA Expression throughout the Light-Dark Cycle Reveal a Strong Regulation of

Andranik Ivanov, Daniele Mattei, Kathrin Radscheit, Anne-Claire Compagnion, Jan Patrick Pett, Hanspeter Herzel, Rosa Chiara Paolicelli, Monika Piwecka, Urs Meyer, Dieter Beule

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. The history and function of a circular RNA.Nature communications · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Andranik IvanovCore Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Daniele MatteiMSSM Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kathrin RadscheitMax-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.
Anne-Claire CompagnionDepartment of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Jan Patrick PettCellular Genetics Programme, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-5249-444X
Hanspeter HerzelInstitute for Theoretical Biology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0003-0414-7889
Rosa Chiara PaolicelliDepartment of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland.ORCID 0000-0001-6851-0849
Monika PiweckaDepartment of Non-Coding RNAs, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Urs MeyerInstitute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, 8057 Zurich, Switzerland.ORCID 0000-0001-7244-0345
Dieter BeuleCore Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEUniversity of Lausanne · CHCharité - Universitätsmedizin Berlin · DEIcahn School of Medicine at Mount Sinai · USInstitute of Bioorganic Chemistry, Polish Academy of Sciences · PLMax Delbrück Center · DEUniversity of Zurich · CHWellcome Sanger Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a large class of relatively stable RNA molecules that are highly expressed in animal brains. Many circRNAs have been associated with CNS disorders accompanied by an aberrant wake-sleep cycle. However, the regulation of circRNAs in brain homeostasis over daily light-dark (LD) cycles has not been characterized. Here, we aim to quantify the daily expression changes of circRNAs in physiological conditions in healthy adult animals. Using newly generated and public RNA-Seq data, we monitored circRNA expression throughout the 12:12 h LD cycle in various mouse brain regions. We identified that

Indexed as

PhotoperiodRNA, CircularAnimalsCircadian RhythmLightMiceSuprachiasmatic NucleusRNA, CircularCdr1ascircadian rhythmcircular RNA (circRNA)Cyranolight-darklight entrainmentmiR-7non-coding RNASCNsuprachiasmatic nucleuswake-sleep

Identifiers

PMID36293208
PMCPMC9604060
OpenAlexW4306385400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.