Evidence map›Paper›PMID 36293184›Full record

ReviewInternational journal of molecular sciences2022

Cancer Stem Cells in Hepatocellular Carcinoma: Intrinsic and Extrinsic Molecular Mechanisms in Stemness Regulation.

Xiaona Fang, Qian Yan, Shan Liu, Xin-Yuan Guan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xiaona FangDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518000, China.ORCID 0000-0001-5325-4686
Qian YanGuangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0001-6549-8135
Shan LiuDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong 999077, China.
Xin-Yuan GuanDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518000, China.ORCID 0000-0003-1874-9805
Chinese University of Hong Kong · HKJinan University · CNSun Yat-sen University · CN

Funding

Hong Kong Research Grant Council including Collaborative Research Funds C4039-19GFHong Kong Research Grant Council including Collaborative Research Funds C7026-18GFHong Kong Research Grant Council including Collaborative Research Funds C7065-18GFNational Natural Science Foundation of China 81903049Shenzhen Fundamental Research Program JCYJ20180508153249223Shenzhen Science and Technology Program KQTD20180411185028798
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains the most predominant type of liver cancer with an extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the culprits for HCC recurrence and metastasis is the existence of cancer stem cells (CSCs), which are a small subset of cancer cells possessing robust stem cell properties within tumors. CSCs play crucial roles in tumor heterogeneity constitution, tumorigenesis, tumor relapse, metastasis, and resistance to anti-cancer therapies. Elucidation of how these CSCs maintain their stemness features is essential for the development of CSCs-based therapy. In this review, we summarize the present knowledge of intrinsic molecules and signaling pathways involved in hepatic CSCs, especially the CSC surface markers and associated signaling in regulating the stemness characteristics and the heterogeneous subpopulations within the CSC pool. In addition, we recapitulate the effects of crucial extrinsic cellular components in the tumor microenvironment, including stromal cells and immune cells, on the modulation of hepatic CSCs. Finally, we synopsize the currently valuable CSCs-targeted therapy strategies based on intervention in these intrinsic and extrinsic molecular mechanisms, in the hope of shedding light on better clinical management of HCC patients.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansNeoplasm Recurrence, LocalNeoplastic Stem CellsTumor Microenvironmentcancer stem cellscell surface markersCSCs-targeting therapieshepatocellular carcinomaheterogeneityimmune cellsstroma cells

Identifiers

PMID36293184
PMCPMC9604119
OpenAlexW4306385401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.