Evidence map›Paper›PMID 36293113›Full record

ArticleInternational journal of molecular sciences2022

KLK12 Regulates MMP-1 and MMP-9 via Bradykinin Receptors: Biomarkers for Differentiating Latent and Active Bovine Tuberculosis.

Yuanzhi Wang, Mengjin Qu, Yiduo Liu, Haoran Wang, Yuhui Dong, Xiangmei Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Macrophage states and polarization duringFrontiers in cellular and infection microbiology · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuanzhi WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-1586-0823
Mengjin QuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yiduo LiuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-2869-5484
Haoran WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yuhui DongCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xiangmei ZhouCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-1566-5745
China Agricultural University · CN

Funding

National Key Research and Development Program 2021YFD1800405National Natural Science Foundation of China 31873005National Natural Science Foundation of China 32172800
6 · The paper itself

Abstract

It has been established that kallikrein12 (KLK12) expression is closely related to bovine tuberculosis (bTB) development. Herein, we sought to clarify the regulatory mechanism of KLK12 and its application in tuberculosis diagnosis. KLK12 knockdown macrophages were produced by siRNA transfection. Bradykinin receptors (BR, including B1R and B2R) were blocked with specific inhibitors. Mannose-capped lipoarabinomannan (ManLAM) was extracted from

Indexed as

Mycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis, BovineAnimalsAntigens, BacterialBiomarkersCattleHumansKallikreinsMannoseMatrix Metalloproteinase 1Matrix Metalloproteinase 9MiceReceptors, BradykininRNA, Small InterferingAntigens, BacterialBiomarkersKallikreinsKLK12 protein, humanMannoseMatrix Metalloproteinase 1Matrix Metalloproteinase 9Receptors, BradykininRNA, Small InterferingdiagnosisKLK12latent tuberculosis infectionMycobacterium bovis

Identifiers

PMID36293113
PMCPMC9603359
OpenAlexW4306385632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.