Evidence map›Paper›PMID 36293094›Full record

ArticleInternational journal of molecular sciences2022

Anticoagulants as Potential SARS-CoV-2 M

Ayman Abo Elmaaty, Wagdy M Eldehna, Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed N El-Taweel, Sara T Al-Rashood, Mohammed A S Abourehab, Faizah A Binjubair, Mohamed A Saleh and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

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  9. Consensus Pharmacophore Strategy For Identifying Novel SARS-Cov-2 MJournal of chemical information and modeling · 2024
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  10. Discovery of Pyrano[2,3-Pharmaceuticals (Basel, Switzerland) · 2024
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  12. Acta pharmaceutica Sinica. B · 2024
    Review
  13. Article
  14. Identification of sulphonamide-tetheredJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 5 countries.

Ayman Abo ElmaatyDepartment of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.ORCID 0000-0002-4634-3039
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0001-6996-4017
Muhammad KhattabDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, El-Buhouth St., Dokki, Cairo 12622, Egypt.ORCID 0000-0002-9086-8983
Omnia KutkatCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
Radwan AlnajjarDepartment of Chemistry, Faculty of Science, University of Benghazi, Benghazi 16063, Libya.ORCID 0000-0003-1869-9596
Ahmed N El-TaweelCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
Sara T Al-RashoodDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, United Arab Emirates.
Mohammed A S AbourehabDepartment of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, United Arab Emirates.ORCID 0000-0003-1348-6567
Faizah A BinjubairDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, United Arab Emirates.
Mohamed A SalehDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.ORCID 0000-0002-6405-6033
Amany BelalMedicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0003-1045-0163
Ahmed A Al-KarmalawyPharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt.ORCID 0000-0002-8173-6073
National Research Centre · EGKing Saud University · SAAhram Canadian University · EGBeni-Suef University · EGKafrelsheikh University · EGMansoura University · EGPort Said University · EGUmm al-Qura University · SAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, 34 anticoagulant drugs were screened in silico against the main protease (M

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2AnticoagulantsAntiviral AgentsCoronavirus 3C ProteasesDabigatranEptifibatideFondaparinuxGentian VioletHeparinHumansMolecular Docking SimulationMolecular Dynamics SimulationProtease InhibitorsTicagrelorViral Nonstructural ProteinsAnticoagulantsAntiviral AgentsCoronavirus 3C ProteasesDabigatranEptifibatideFondaparinuxGentian VioletHeparinProtease InhibitorsTicagrelorViral Nonstructural Proteinsanticoagulantsin silicoin vitroMproSARS-CoV-2

Identifiers

PMID36293094
PMCPMC9603561
OpenAlexW4306152110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.