ArticleInternational journal of molecular sciences2022
Role of Endothelial STAT3 in Cerebrovascular Function and Protection from Ischemic Brain Injury.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment.International journal of molecular medicine · 2026Article
- Clinical Characteristics and Gene Expression of JAK2, STAT3, miRNA-155, and miRNA-216a in Young Adults with Acute Ischemic Stroke.International journal of molecular sciences · 2026Article
- Identification of potential therapeutic targets for stroke and its subtypes by integrating proteomes and genetics from human plasma.Brain communications · 2026Article
- APEX1-STAT3 signaling mediates the force-coordinated endothelial regeneration.Cellular and molecular life sciences : CMLS · 2025Article
- Acupuncture ameliorates inflammation by regulating gut microbiota in acute ischemic stroke.IBRO neuroscience reports · 2025Article
- Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.Scientific reports · 2025Article
- Discovery of KDM5D as a novel biomarker for traumatic brain injury identified through bioinformatics analysis.Frontiers in immunology · 2025Article
- Validation of machine learning application for the identification of lipid metabolism-associated diagnostic model in ischemic stroke.International journal of clinical and experimental pathology · 2025Article
- Vascular Aging in Ischemic Stroke.Journal of the American Heart Association · 2024Review
- High-throughput drug screening to investigate blood-brain barrier permeabilityFrontiers in drug delivery · 2024Article
- A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation.Journal of translational internal medicine · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
STAT3 plays a protective role against ischemic brain injury; however, it is not clear which brain cell type mediates this effect, and by which mechanism. We tested the hypothesis that endothelial STAT3 contributes to protection from cerebral ischemia, by preserving cerebrovascular endothelial function and blood-brain barrier (BBB) integrity. The objective of this study was to determine the role of STAT3 in cerebrovascular endothelial cell (EC) survival and function, and its role in tissue outcome after cerebral ischemia. We found that in primary mouse brain microvascular ECs, STAT3 was constitutively active, and its phosphorylation was reduced by oxygen-glucose deprivation (OGD), recovering after re-oxygenation. STAT3 inhibition, using two mechanistically different pharmacological inhibitors, increased EC injury after OGD. The sub-lethal inhibition of STAT3 caused endothelial dysfunction, demonstrated by reduced nitric oxide release in response to acetylcholine and reduced barrier function of the endothelial monolayer. Finally, mice with reduced endothelial STAT3 (Tie2-Cre; STAT3
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