Evidence map›Paper›PMID 36292952›Full record

ArticleInternational journal of molecular sciences2022

WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy.

Chia-Ying Hou, Chung-Yung Ma, Yu-Ju Lin, Chou-Long Huang, Horng-Dar Wang, Chiou-Hwa Yuh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  4. Silencing PPP2R1A inhibits the progression of gastric cancer cells.Journal of cancer research and clinical oncology · 2025
    Article
  5. Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells.Biochemistry research international · 2025
    Article
  6. Article
  7. Zebrafish live imaging: a strong weapon in anticancer drug discovery and development.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Chia-Ying HouInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Chung-Yung MaInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Yu-Ju LinInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Chou-Long HuangDivision of Nephrology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Horng-Dar WangInstitute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0001-9570-3611
Chiou-Hwa YuhInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.ORCID 0000-0002-2356-1551
National Health Research Institutes · TWNational Tsing Hua University · TWNational Yang Ming Chiao Tung University · TWUniversity of Iowa · US

Funding

WNK kinase cascade in health and diseaseR01DK111542 · NIDDK · UNIVERSITY OF IOWA · PI Chou-Long Huang · 2017 to 2026
$3.6M
National Health Research Institutes MG-109-PP-06National Science and Technology Council 108-2320-B-400-005-MY3National Science and Technology Council 110-2320-B-007-003NIDDK NIH HHS R01 DK111542NIH HHS DK111542
6 · The paper itself

Abstract

Lysine-deficient protein kinase-1 (WNK1) is critical for both embryonic angiogenesis and tumor-induced angiogenesis. However, the downstream effectors of WNK1 during these processes remain ambiguous. In this study, we identified that oxidative stress responsive 1b (

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsbeta-GalactosidaseHumansHuman Umbilical Vein Endothelial CellsIntracellular Signaling Peptides and ProteinsLysineMinor Histocompatibility AntigensNeovascularization, PathologicProtein Phosphatase 2Protein Serine-Threonine KinasesRafoxanideTranscription FactorsTumor Suppressor Protein p53WNK Lysine-Deficient Protein Kinase 1beta-GalactosidaseIntracellular Signaling Peptides and ProteinsLysineMinor Histocompatibility AntigensProtein Phosphatase 2Protein Serine-Threonine KinasesRafoxanideTranscription FactorsTumor Suppressor Protein p53WNK Lysine-Deficient Protein Kinase 1hepatocellular carcinoma (HCC)lysine-deficient protein kinase-1 (WNK1)oxidative stress responsive 1 (OSR1)Protein Phosphatase 2A (PP2A)tumor-induced angiogenesis

Identifiers

PMID36292952
PMCPMC9602556
OpenAlexW4304588417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.