Evidence map›Paper›PMID 36292948›Full record

ArticleInternational journal of molecular sciences2022

Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of

Sean Wiere, Christopher Sugai, Michael J Espiritu, Vincent P Aurelio, Chloe D Reyes, Nicole Yuzon, Randy M Whittal, Jan Tytgat, Steve Peigneur, Jon-Paul Bingham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Sean WiereDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Christopher SugaiDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Michael J EspirituDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Vincent P AurelioDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Chloe D ReyesDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Nicole YuzonDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.
Randy M WhittalDepartment of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.
Jan TytgatToxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg O&N II, 3000 Leuven, Belgium.
Steve PeigneurToxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg O&N II, 3000 Leuven, Belgium.ORCID 0000-0003-0504-5702
Jon-Paul BinghamDepartment of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawai'i, Honolulu, HI 96822, USA.ORCID 0000-0001-6420-8634
University of Hawaii System · USKU Leuven · BEPacific University Oregon · USUniversity of Alberta · CA

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

The marine cone snail produces one of the fastest prey strikes in the animal kingdom. It injects highly efficacious venom, often causing prey paralysis and death within seconds. Each snail has hundreds of conotoxins, which serve as a source for discovering and utilizing novel analgesic peptide therapeutics. In this study, we discovered, isolated, and synthesized a novel α3/5-conotoxins derived from the milked venom of

Indexed as

ConotoxinsConus SnailReceptors, NicotinicAnimalsBioengineeringPeptidesProlineTryptophanVenomsConotoxinsPeptidesProlineReceptors, NicotinicTryptophanVenomsanalogbioassayConus obscurusIC50LD50mass spectrometrymilked venomnAChRpost-translational modificationsα-conotoxin

Identifiers

PMID36292948
PMCPMC9602734
OpenAlexW4304588923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.