Evidence map›Paper›PMID 36292934›Full record

ArticleInternational journal of molecular sciences2022

Exploring the Mystery of the Tetrahydrobiopterin Synthetic Defect Lethal Mutant

Dan Liang, Rui Shu, Song Jiang, Mengjun Xu, Yangyang Cai, Hongwei Qin, Daobo Zhang, Mengwei Feng, Junshan Gao, Yan Meng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dan LiangSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Rui ShuSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Song JiangSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Mengjun XuSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Yangyang CaiSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Hongwei QinSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Daobo ZhangSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Mengwei FengSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Junshan GaoSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.
Yan MengSchool of Life Sciences, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China.ORCID 0000-0003-3155-8536
Anhui Agricultural University · CN

Funding

Innovative Research Groups of Anhui Agricultural University ANRC2019032International Science & Technology Cooperation Plan of Anhui Province 2022h11020020National Natural Science Foundation of China 31572468National Natural Science Foundation of China 31672497National Natural Science Foundation of China 31872423
6 · The paper itself

Abstract

Tetrahydrobiopterin (BH4) is a vital coenzyme for several enzymes involved in diverse enzymatic reactions in animals, and BH4 deficiency can lead to metabolic and neurological disorders due to dysfunction in its metabolism. In the silkworm natural homozygous mutant

Indexed as

BombyxPhenylketonuriasAnimalsBiopterinsHumansMelaninsNitric Oxide SynthaseBiopterinsMelaninsNitric Oxide Synthasesapropterinapoptosis systemimmune systemmaternal effectmitochondrial damageoxidative stress

Identifiers

PMID36292934
PMCPMC9603568
OpenAlexW4304588618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.