Evidence map›Paper›PMID 36292924›Full record

ArticleInternational journal of molecular sciences2022

Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver.

Chenxi Piao, Jinfang Sang, Zhipeng Kou, Yue Wang, Tao Liu, Xiangyu Lu, Zhihui Jiao, Hongbin Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chenxi PiaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Jinfang SangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Zhipeng KouCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yue WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Tao LiuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Xiangyu LuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Zhihui JiaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Hongbin WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0002-4454-3328
Northeast Agricultural University · CN

Funding

National Natural Science Foundation of China 31972757
6 · The paper itself

Abstract

Although accumulating evidence indicates that exosomes have a positive therapeutic effect on hepatic ischemia-reperfusion injury (HIRI), studies focusing on the alleviation of liver injury by exosomes derived from adipose-derived mesenchymal stem cells (ADSCs-Exo) based on the inhibition of cell pyroptosis have not yet been reported. Exosomes contain different kinds of biologically active substances such as proteins, lipids, mRNAs, miRNAs, and signaling molecules. These molecules are widely involved in cell-cell communication, cell signal transmission, proliferation, migration, and apoptosis. Therefore, we investigated the positive effects exerted by ADSCs-Exo after hepatic ischemia-reperfusion with partial resection injury in rats. In this study, we found that the post-operative tail vein injection of ADSCs-Exo could effectively inhibit the expression of pyroptosis-related factors such as NLRP3, ASC, caspase-1, and GSDMD-N, and promote the expression of regeneration-related factors such as Cyclin D1 and VEGF. Moreover, we found that the above cellular activities were associated with the NF-κB and Wnt/β-catenin signaling pathways. According to the results, ADSCs and ADSCs-Exo can reduce pyroptosis in the injured liver and promote the expression of those factors related to liver regeneration, while they can inhibit the NF-κB pathway and activate the Wnt/β-catenin pathway. However, although adipose-derived mesenchymal stem cell (ADSC) transplantation can reduce liver injury, it leads to a significant increase in the pyroptosis-related protein GSDMD-N expression. In conclusion, our study shows that ADSCs-Exo has unique advantages and significance as a cell-free therapy to replace stem cells and still has a broad research prospect in the clinical diagnosis and treatment of liver injuries.

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsAdipose TissueAnimalsbeta CateninCaspasesCyclin D1LipidsLiverNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisRatsVascular Endothelial Growth Factor Abeta CateninCaspasesCyclin D1LipidsMicroRNAsNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinVascular Endothelial Growth Factor AADSCs-Exohepatic ischemia–reperfusion injuryliver regenerationpyroptosisrats

Identifiers

PMID36292924
PMCPMC9602906
OpenAlexW4304610761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.