Evidence map›Paper›PMID 36292708›Full record

ArticleGenes2022

New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension.

Polina V Alyabyeva, Olga V Chastina, Marina M Petrova, Natalia V Lareva, Natalia P Garganeeva, Galina A Chumakova, Marina S Cherniaeva, Natalia A Shnayder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Polina V AlyabyevaShared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.ORCID 0000-0002-8833-1052
Olga V ChastinaShared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.
Marina M PetrovaShared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.
Natalia V LarevaDepartment of Therapy of Faculty of Postgraduate Education, Chita State Medical Academy, 672000 Chita, Russia.
Natalia P GarganeevaDepartment of General Medical Practice and Outpatient Therapy, Siberian State Medical University, 634050 Tomsk, Russia.
Galina A ChumakovaDepartment of Therapy and General Medical Practice with a Course of Additional Professional Education, Altai State Medical University, 656038 Barnaul, Russia.
Marina S CherniaevaDepartment of Internal and Preventive Medicine, Central State Medical Academy of the Presidential Administration, 121359 Moscow, Russia.ORCID 0000-0003-3091-7904
Natalia A ShnayderShared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.ORCID 0000-0002-2840-837X
Krasnoyarsk State Medical University · RUAltai State Medical University · RUCentral State Medical Academy · RUChita State Academy of Medicine · RUSiberian State Medical University · RUSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. Reduced bioavailability of NO in the endothelium is an important precursor for impaired vasodilation and arterial hypertension (AH). Furthermore, NO is involved in nociceptive processing. A NO-induced biphasic response with immediate and a delayed headache is typical for chronic tension-type headaches (TTH) in humans. The aim was to study the association of allelic variants and genotypes of the single nucleotide variant (SNV) rs3782218 of the MATERIALS AND

methodsWe observed 91 Caucasian participants who resided in Krasnoyarsk city: group 1 (TTH and AH overlap syndrome)-30 patients; group 2 (AH without headache)-30 patients; group 3 (control)-31 healthy volunteers. The diagnosis of AH was based on criteria of the European Society of Cardiology and the European Society of Hypertension (2018) и criteria of the Russian Society of Cardiology (2020). Diagnosis of TTH was based on criteria of the International Classification of Headache Disorders (2018). Real-time polymerase chain reaction was used for the determination of allelic variants and genotypes of the SNV rs3782218 of the

resultsThe frequency of the minor allele T of rs3782218 was statistically significantly higher by 16.7 times in group 1 (TTH and AH) compared to group 3 (control): 26.7% versus 1.6%, respectively (

conclusionThus, the minor allele T of rs3782218 of the

Indexed as

HypertensionTension-Type HeadacheAdultBiomarkersHeadacheHumansMiddle AgedNitric OxideNucleotidesSyndromeBiomarkersNitric OxideNucleotidesarterial hypertensioncomorbiditygenetic biomarkernitric oxideNOS1overlap syndromers3782218tension-type headache

Identifiers

PMID36292708
PMCPMC9602376
OpenAlexW4303946169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.