Evidence map›Paper›PMID 36292683›Full record

ArticleGenes2022

Robust Genetic Analysis of the X-Linked Anophthalmic (

Brianda A Hernandez-Moran, Andrew S Papanastasiou, David Parry, Alison Meynert, Philippe Gautier, Graeme Grimes, Ian R Adams, Violeta Trejo-Reveles, Hemant Bengani, Margaret Keighren and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Brianda A Hernandez-MoranMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.ORCID 0000-0001-5405-0757
Andrew S PapanastasiouMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.ORCID 0000-0002-8888-0633
David ParryMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Alison MeynertMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Philippe GautierMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.ORCID 0000-0003-3019-6262
Graeme GrimesMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Ian R AdamsMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Violeta Trejo-RevelesThe Division of Functional Genetics and Development, The Roslin Institute, Midlothian EH25 9RG, UK.
Hemant BenganiMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Margaret KeighrenMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Ian J JacksonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
David J AdamsWellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
David R FitzPatrickMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Rd South, Edinburgh EH4 2XU, UK.
Joe RaingerThe Division of Functional Genetics and Development, The Roslin Institute, Midlothian EH25 9RG, UK.ORCID 0000-0003-1091-5100
Institute of Genetics and Cancer · GBRoslin Institute · GBWellcome Sanger Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/10002071Medical Research Council MC_UU_00007/3Medical Research Council MC_UU_00007/4Medical Research Council MC_UU_00007/6Medical Research Council MC_UU_00009/2Medical Research Council MR/S033165/1
6 · The paper itself

Abstract

Anophthalmia (missing eye) describes a failure of early embryonic ocular development. Mutations in a relatively small set of genes account for 75% of bilateral anophthalmia cases, yet 25% of families currently are left without a molecular diagnosis. Here, we report our experimental work that aimed to uncover the developmental and genetic basis of the anophthalmia characterising the X-linked

Indexed as

AnophthalmosAnimalsChromatinDNAHomeodomain ProteinsMaleMiceRegulatory Sequences, Nucleic AcidTranscription FactorsChromatinDNAHomeodomain ProteinsTranscription FactorsZic3 protein, mouseanophthalmiaeye developmentgenome wide analysislinkage analysisX-chromosomeX-ray induced alleleZic3

Identifiers

PMID36292683
PMCPMC9601528
OpenAlexW4303685674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.