Evidence map›Paper›PMID 36292629›Full record

ArticleGenes2022

Classification of Protein Sequences by a Novel Alignment-Free Method on Bacterial and Virus Families.

Mengcen Guan, Leqi Zhao, Stephen S-T Yau

Abstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mengcen GuanDepartment of Mathematical Sciences, Tsinghua University, Beijing 100084, China.
Leqi ZhaoDepartment of Mathematical Sciences, Tsinghua University, Beijing 100084, China.
Stephen S-T YauDepartment of Mathematical Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-7634-7981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The classification of protein sequences provides valuable insights into bioinformatics. Most existing methods are based on sequence alignment algorithms, which become time-consuming as the size of the database increases. Therefore, there is a need to develop an improved method for effectively classifying protein sequences. In this paper, we propose a novel accumulated natural vector method to cluster protein sequences at a lower time cost without reducing accuracy. Our method projects each protein sequence as a point in a 250-dimensional space according to its amino acid distribution. Thus, the biological distance between any two proteins can be easily measured by the Euclidean distance between the corresponding points in the 250-dimensional space. The convex hull analysis and classification perform robustly on virus and bacteria datasets, effectively verifying our method.

Indexed as

Amino AcidsBacteriaAmino Acid SequencePhylogenySequence AlignmentAmino Acidsaccumulated natural vectoralignment-freeclassificationconvex hull methodproteins

Identifiers

PMID36292629
PMCPMC9602327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.