ReviewHealthcare (Basel, Switzerland)2022
Spinal Cord Stimulation in Chronic Low Back Pain Syndrome: Mechanisms of Modulation, Technical Features and Clinical Application.
Review in Healthcare (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of dual direct and alternating currents on pain induced by blood sampling and intramuscular injection processes.Pain management · 2025Trial
- Spinal cord stimulation: An emerging strategy for chronic pain relief after spinal cord injury.Neural regeneration research · 2026Article
- A case series of two patients using closed-loop spinal cord stimulation: demonstration of the impact of real-time adjustments.Journal of surgical case reports · 2026Article
- Spinal Cord Stimulation as a Potential Therapeutic Modality for Managing Concurrent Chronic Low Back and Abdominal Pain Complicated by Device Migration: A Case Report.Clinical case reports · 2026Article
- MuscleSCS: a standardized programming framework combining neural neuromodulation and spinally mediated paraspinal muscle modulation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Spinal Cord Stimulation: Mechanisms of Action, Indications, Types, Complications.Journal of clinical medicine · 2025Review
- Article
- Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain.Journal of anesthesia, analgesia and critical care · 2024Review
- Neuromodulation techniques - From non-invasive brain stimulation to deep brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Large-scale real-world data on a multidisciplinary approach to spinal cord stimulation for persistent spinal pain syndromes: first evaluation of the Neuro-PainFrontiers in neuroscience · 2024Article
- Digital Therapeutics (DTx) Expand Multimodal Treatment Options for Chronic Low Back Pain: The Nexus of Precision Medicine, Patient Education, and Public Health.Healthcare (Basel, Switzerland) · 2023Article
- "Neuro-Fiber Mapping": An Original Concept of Spinal Cord Neural Network Spatial Targeting Using Live Electrostimulation Mapping to (Re-)Explore the Conus Medullaris Anatomy.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic low-back pain (CLBP) is a common disease with several negative consequences on the quality of life, work and activity ability and increased costs to the health-care system. When pharmacological, psychological, physical and occupational therapies or surgery fail to reduce CLBP, patients may be a candidate for Spinal Cord Stimulation (SCS). SCS consists of the transcutaneous or surgical implantation of different types of electrodes in the epidural space; electrodes are then connected to an Implanted Pulse Generator (IPG) that generates stimulating currents. Through spinal and supraspinal mechanisms based on the "gate control theory for pain transmission", SCS reduces symptoms of CLBP in the almost totality of well-selected patients and its effect lasts up to eight years in around 75% of patients. However, the evidence in favor of SCS still remains weak, mainly due to poor trial methodology and design. This narrative review is mainly addressed to those professionals that may encounter patients with CLBP failing conventional treatments. For this reason, we report the mechanisms of pain relief during SCS, the technical features and some clinical considerations about the application of SCS in patients with CLBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.