ArticleDiagnostics (Basel, Switzerland)2022
Determination of the Accuracy of Salivary Biomarkers for Periodontal Diagnosis.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Obstructive Sleep Apnea and Periodontitis: A Systematic Umbrella Review.Clinical and experimental dental research · 2026Pooled it
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- Diagnostic Accuracy Studies: Sensitivity, Specificity, and Beyond.Journal of periodontal research · 2026Article
- TAM pathway proteins as novel salivary biomarkers for periodontitis.Journal of periodontology · 2026Observational
- Salivary Biomarker Profile in Periodontal Diseases: A Cross-Sectional Study on Leptin, Adiponectin, and Calprotectin.Diagnostics (Basel, Switzerland) · 2025Article
- Salivary Biomarkers in Periodontal Disease: Revolutionizing Early Detection and Precision Dentistry.Molecular diagnosis & therapy · 2025Review
- Comparison of Supervised Machine Learning Models to Logistic Regression Model Using Tooth-Related Factors to Predict the Outcome of Nonsurgical Periodontal Treatment.Diagnostics (Basel, Switzerland) · 2025Article
- Matrix Metalloproteinase Inhibitors and Their Potential Clinical Application in Periodontitis.Diseases (Basel, Switzerland) · 2025Review
- Recasting of Periodontal Diagnosis.Journal of pharmacy & bioallied sciences · 2025Review
- Changes in MMP-9, T-SOD and SIRT-1 levels after non-surgical periodontal treatment.BMC oral health · 2025Article
- Increased bacterial load ofFrontiers in oral health · 2025Article
- Periodontal Molecular Diagnostics: State of Knowledge and Future Prospects for Clinical Application.International journal of molecular sciences · 2024Review
- Investigating the role of salivary Interleukin-40 levels in diagnosing periodontal diseases.Oral diseases · 2024Article
- Microbiological and Salivary Biomarkers Successfully Predict Site-Specific and Whole-Mouth Outcomes of Nonsurgical Periodontal Treatment.Journal of clinical medicine · 2024Article
- Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.International journal of molecular sciences · 2024Review
- Evaluation of NETosis (Neutrophil Extracellular Traps) biomarkers in smokers and nonsmokers periodontitis patients.F1000Research · 2024Article
- Diagnostic Potential of Salivary Interleukin-1International journal of dentistry · 2024Article
- Absent in Melanoma 2 Gene Associated Periodontitis and Coronary Heart Disease.F1000Research · 2024Article
- Dysregulation ofCurrent Alzheimer research · 2024Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate the accuracy of salivary matrix metalloproteinases (MMP)-8 and -9, and tissue inhibitor of metalloproteinase (TIMP)-1 in diagnosing periodontitis and in distinguishing periodontitis stages (S)1 to S3.
methodsThis study was a case-control study that included patients with periodontitis S1 to S3 and subjects with healthy periodontia (controls). Saliva was collected, and then, clinical parameters were recorded, including plaque index, bleeding on probing, probing pocket depth, and clinical attachment level. Diagnosis was confirmed by assessing the alveolar bone level using radiography. Salivary biomarkers were assayed using an enzyme-linked immunosorbent assay.
resultsA total of 45 patients (15 for each stage) and 18 healthy subjects as controls were included. The levels of all salivary biomarkers and clinical parameters were significantly higher in periodontitis subjects than in the controls. The ROC curve showed that MMP-8, MMP-9, TIMP-1, MMP-8/TIMP-1, and MMP-9/TIMP-1 had statistically significant diagnostic accuracy, with areas under the curve (AUCs) of 0.892, 0.844, 0.920, 0.986, and 1.000, respectively, when distinguishing periodontitis from the controls. Similarly, these biomarkers showed significant diagnostic accuracy in the differentiation of S1 periodontitis from the controls (AUC range from 0.902 to 1.000).
conclusionsThis study suggested that salivary biomarkers exhibited high diagnostic accuracy in distinguishing periodontal health from periodontitis in general as well as S1 periodontitis. Furthermore, TIMP-1 could differentiate S1 from S3.
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