ArticleDiagnostics (Basel, Switzerland)2022
Herlyn-Werner-Wunderlich Syndrome: Case Report and Review of the Literature.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 12 citations in OpenAlex.
- Fertility, Pregnancy, and Psychological Burden in OHVIRA Syndrome: Clinical Case Study and Review of the Literature.Journal of clinical medicine · 2026Article
- Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance.Clinical genetics · 2026Review
- Uterus didelphys without vaginal septum identified intraoperatively at cesarean delivery: a case report.International journal of surgery case reports · 2026Article
- Herlyn-Werner-Wunderlich syndrome in three infants: a case report of surgical treatment.Frontiers in pediatrics · 2026Article
- Kidney Agenesis and Müllerian Duct Anomalies: A Report of Two Cases and Literature Review.Acta medica Lituanic · 2025Article
- Acute urinary retention in an adolescent female with Herlyn-Werner-Wunderlich syndrome.Annals of medicine and surgery (2012) · 2025Article
- Endometriosis Coinciding with Uterus Didelphys and Renal Agenesis: A Literature Review.Journal of clinical medicine · 2024Review
- Article
- A rare case report of Herlyn-Werner-Wunderlich syndrome: Unraveling unusual urinary anomalies and literature review.Heliyon · 2024Article
- Herlyn-Werner-Wunderlich Syndrome Complicated with Vesicovaginal Fistula: A Rare Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- Article
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3 authors at 1 institution in 1 country.
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Abstract
Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital malformation of the urogenital tract involving both the müllerian and the wolffian ducts, and it consists of the association of didelphys uterus, ipsilateral obstructed hemivagina, and ipsilateral kidney agenesis. Its etiology is related to the abnormal development of two embryonic structures-mesonephros and paramesonephros-although its precise mechanism is not known, but theories involving signaling molecules and gene expression are studied for potential explanations. Because of its rarity, there is limited literature on this subject. We present a case diagnosed in our department and elaborate on management. In HWW syndrome, symptoms appear after menarche and include pelvic pain, with progressive intensity due to the developing of hematocolpos. Menstruation may be present or absent depending on the type of anomaly. The use of magnetic resonance imaging (MRI) is the most recommended method of investigation since, in most cases, at this age, sexual life has not started yet and transvaginal ultrasound cannot be used. Surgical treatment in our case consisted of an exploratory laparoscopy followed by a vaginal surgical approach to resect the vaginal septum of the obstructed hemivagina.
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