Evidence map›Paper›PMID 36292125›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Concordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions.

Frederik A Stuebs, Anna K Dietl, Annika Behrens, Werner Adler, Carol Geppert, Arndt Hartmann, Antje Knöll, Matthias W Beckmann, Grit Mehlhorn, Carla E Schulmeyer and 2 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Frederik A StuebsDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.ORCID 0000-0002-0729-2064
Anna K DietlDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Annika BehrensDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Werner AdlerDepartment of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 6, 91054 Erlangen, Germany.
Carol GeppertInstitute of Pathology, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany.
Arndt HartmannInstitute of Pathology, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany.
Antje KnöllInstitute of Clinical and Molecular Virology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Schlossgarten 4, 91054 Erlangen, Germany.ORCID 0000-0002-1294-6923
Matthias W BeckmannDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Grit MehlhornInstitute of Pathology, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany.
Carla E SchulmeyerDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Paul GassDepartment of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.ORCID 0000-0002-4239-5528
Martin C KochDepartment of Gynecology and Obstetrics, Hospital ANregiomed Ansbach, Escherichstrasse 1, 91522 Ansbach, Germany.ORCID 0000-0002-9148-2652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The purpose of this research is to estimate the rate of concordance, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of colposcopy for high-grade squamous lesions and carcinomas (HSIL+). Methods: We conducted a retrospective study of colposcopies performed in the certified Dysplasia Unit in Erlangen between January 2015 and May 2022 (7.5 years). The colposcopic findings were correlated with biopsies obtained during examinations or surgery. Cases without histology were excluded. The primary outcome was the rate of concordance between the colposcopic and histological findings in relation to the type of transformation zone (TZ), examiner’s level of experience and age of the patients. Results: A total of 4778 colposcopies in 4001 women were analyzed. The rates of concordance for CIN I/LSIL, CIN II/HSIL, CIN III/HSIL, and carcinoma were 43.4%, 59.5%, 78.5%, and 53.9%, respectively. The rate of concordance was lowest for TZ3 and highest for colposcopists with more than 10 years’ experience. Conclusions: Colposcopy is an important, feasible, and effective method. Careful work-up needs to be performed for women with TZ3 who are over 35 years old, as they are at the highest risk of being misdiagnosed. The highest concordance for detecting HSIL+ was seen for colposcopists with >10 years’ experience.

Indexed as

cervical cancercervical cancer screening assessmentcervical intraepithelial neoplasiacolposcopy

Identifiers

PMID36292125
PMCPMC9600163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.