Evidence map›Paper›PMID 36292084›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis.

Irina Y Yanina, Viktor V Nikolaev, Olga A Zakharova, Alexei V Borisov, Konstantin N Dvoretskiy, Kirill V Berezin, Vyacheslav I Kochubey, Yuri V Kistenev, Valery V Tuchin

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Irina Y YaninaInstitute of Physics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0002-6814-556X
Viktor V NikolaevLaboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 634050 Tomsk, Russia.ORCID 0000-0001-8189-0188
Olga A ZakharovaLaboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 634050 Tomsk, Russia.
Alexei V BorisovLaboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 634050 Tomsk, Russia.
Konstantin N DvoretskiyDepartment of Medbiophysics, Saratov State Medical University, 410012 Saratov, Russia.ORCID 0000-0002-8551-4902
Kirill V BerezinInstitute of Physics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0003-0940-0388
Vyacheslav I KochubeyInstitute of Physics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0001-7834-9067
Yuri V KistenevLaboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 634050 Tomsk, Russia.ORCID 0000-0001-5760-1462
Valery V TuchinInstitute of Physics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0001-7479-2694
National Research Tomsk State University · RUSaratov State University · RUSaratov State Medical University · RU

Funding

the Government of the Russian Federation 220
6 · The paper itself

Abstract

In this paper, the measurement and modeling of optical properties in the terahertz (THz) range of adipose tissue and its components with temperature changes were performed. Spectral measurements were made in the frequency range 0.25-1 THz. The structural models of main triglycerides of fatty acids are constructed using the B3LYP/6-31G(d) method and the Gaussian03, Revision B.03 program. The optical density (OD) of adipose tissue samples decreases as temperature increases, which can be associated mostly with the dehydration of the sample. Some inclusion of THz wave scattering suppression into the OD decrease can also be expected due to refractive index matching provided by free fatty acids released from adipocytes at thermally induced cell lipolysis. It was shown that the difference between the THz absorption spectra of water and fat makes it possible to estimate the water content in adipose tissue. The proposed model was verified on the basis of molecular modeling and a comparison with experimental data for terahertz spectra of adipose tissue during its heating. Knowing the exact percentage of free and bound water in adipose tissue can help diagnose and monitor diseases, such as diabetes, obesity, and cancer.

Indexed as

absorption spectraadipose tissuedehydrationmolecular modelingoleic acidterahertz spectroscopywater

Identifiers

PMID36292084
PMCPMC9600075
OpenAlexW4303627960

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.