Evidence map›Paper›PMID 36291920›Full record

ArticleCancers2022

The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research.

Elisabeth Schültke, Stefan Fiedler, Catharina Mewes, Elisabetta Gargioni, Johannes Klingenberg, Guilherme Abreu Faria, Michael Lerch, Marco Petasecca, Franziska Prehn, Marie Wegner and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Elisabeth SchültkeDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
Stefan FiedlerEuropean Molecular Biology Laboratory (EMBL), Hamburg Outstation, 22607 Hamburg, Germany.ORCID 0000-0002-3623-3311
Catharina MewesDepartment of Radiotherapy and Radio-Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Elisabetta GargioniDepartment of Radiotherapy and Radio-Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-8204-0609
Johannes KlingenbergHelmholtz-Zentrum HEREON, 21502 Hamburg, Germany.
Guilherme Abreu FariaHelmholtz-Zentrum HEREON, 21502 Hamburg, Germany.
Michael LerchCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.ORCID 0000-0002-2406-9972
Marco PetaseccaCentre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia.ORCID 0000-0001-5958-7457
Franziska PrehnDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
Marie WegnerInstitute of Product Development and Mechanical Engineering Design, Hamburg University of Technology, 21073 Hamburg, Germany.
Marten ScholzDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
Felix JaekelDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
Guido HildebrandtDepartment of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.
University of Rostock · DEUniversität Hamburg · DEHelmholtz-Zentrum Hereon · DEUniversity of Wollongong · AUEuropean Molecular Biology Laboratory · DE

Funding

German Academic Exchange Service DAAD PPP 57444927German Research Foundation (DFG) SCHU 2589/7-1HEREON travel support no number
6 · The paper itself

Abstract

High dose rate radiotherapies such as FLASH and microbeam radiotherapy (MRT) both have developed to the stage of first veterinary studies within the last decade. With the development of a new research tool for high dose rate radiotherapy at the end station P61A of the synchrotron beamline P61 on the DESY campus in Hamburg, we increased the research capacity in this field to speed up the translation of the radiotherapy techniques which are still experimental, from bench to bedside. At P61, dose rates of several hundred Gy/s can be delivered. Compared to dedicated biomedical beamlines, the beam width available for MRT experiments is a very restrictive factor. We developed two model systems specifically to suit these specific technical parameters and tested them in a first set of experiments.

Indexed as

FLASH radiotherapyhigh dose rate radiotherapymicrobeam radiotherapy (MRT)synchrotron

Identifiers

PMID36291920
PMCPMC9600877
OpenAlexW4306951113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.