Evidence map›Paper›PMID 36291794›Full record

ReviewCancers2022

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma.

Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P Dellavalle, Mayumi Fujita

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
  3. Article
  4. DownregulatedCells · 2025
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takeshi YamauchiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sarah ShangrawDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Zili ZhaiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-5164-3696
Dinoop Ravindran MenonDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-6335-9227
Nisha BattaDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Robert P DellavalleDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Mayumi FujitaDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1498-1925

Funding

The role of IL-37 in human regulatory T cells, SupplementR01AI156534 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2025
$3.0M
Modulation of Inflammasome-mediated cytokine activation by EGCG in human melanomaR01CA197919 · NCI · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2016 to 2020
$1.9M
Ethanol-induced skin changesR21AA028904 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2022
$408k
BLRD VA I01 BX001228NCI NIH HHS R01 CA197919NIAAA NIH HHS R21 AA028904NIAID NIH HHS R01 AI156534
6 · The paper itself

Abstract

Although cancer mortality has declined among the general population, the incidence of melanoma continues to rise. While identifying high-risk cohorts with genetic risk factors improves public health initiatives and clinical care management, recognizing modifiable risk factors such as social-environmental risk factors would also affect the methods of patient outreach and education. One major modifiable social-environmental risk factor associated with melanoma is ultraviolet (UV) radiation. However, not all forms of melanoma are correlated with sun exposure or occur in sun-exposed areas. Additionally, UV exposure is rarely associated with tumor progression. Another social-environmental factor, pregnancy, does not explain the sharply increased incidence of melanoma. Recent studies have demonstrated that alcohol consumption is positively linked with an increased risk of cancers, including melanoma. This perspective review paper summarizes epidemiological data correlating melanoma incidence with alcohol consumption, describes the biochemical mechanisms of ethanol metabolism, and discusses how ethanol and ethanol metabolites contribute to human cancer, including melanoma.

Indexed as

acetaldehydealcoholalcohol dehydrogenasealdehyde dehydrogenaseethanolethanol metabolismmelanomaultraviolet radiation

Identifiers

PMID36291794
PMCPMC9599745

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.