Evidence map›Paper›PMID 36291788›Full record

ArticleCancers2022

Intraoperative Extra Corporeal Membrane Oxygenator for Lung Cancer Resections Does Not Impact Circulating Tumor Cells.

Francesco Petrella, Laura Zorzino, Samuele Frassoni, Vincenzo Bagnardi, Monica Casiraghi, Claudia Bardoni, Shehab Mohamed, Valeria Musso, Emanuele Simonini, Fabiana Rossi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Francesco PetrellaDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.ORCID 0000-0001-5945-1576
Laura ZorzinoDivision of Laboratory Medicine, IRCCS European Institute of Oncology, 20141 Milan, Italy.ORCID 0000-0002-8596-1649
Samuele FrassoniDepartment of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-4265-2627
Vincenzo BagnardiDepartment of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.
Monica CasiraghiDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.ORCID 0000-0001-5986-7811
Claudia BardoniDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.
Shehab MohamedDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.ORCID 0000-0002-3157-3720
Valeria MussoDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.ORCID 0000-0003-4102-7237
Emanuele SimoniniDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.
Fabiana RossiDepartment of Cardiovascular Surgery, IRCCS Centro Cardiologico Monzino, 20138 Milan, Italy.
Francesco AlamanniDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Marco VenturinoDepartment of Anesthesiology, IRCCS European Institute of Oncology, 20141 Milan, Italy.
Lorenzo SpaggiariDepartment of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy.
European Institute of Oncology · ITUniversity of Milan · ITUniversity of Milano-Bicocca · ITCentro Cardiologico Monzino · IT

Funding

Italian Ministry of helath " 5 x mille" fund
6 · The paper itself

Abstract

backgroundThe diagnosis of active neoplastic disease was traditionally judged an absolute contraindication for extracorporeal membrane oxygenator (ECMO) because of the fear of tumor cells being scattered or seeded. The aim of this study is to compare the number of circulating tumor cells (CTCs) before and after surgery in patients receiving lung cancer resection with and without intraoperative ECMO support.

methodsThis is a prospective, non-randomized, two-arms observational study comparing the number of CTCs before and after surgery in patients receiving lung cancer resection with and without intraoperative ECMO support. The ECMO arm includes patients suffering from lung cancer undergoing pulmonary resection with planned intraoperative ECMO support. The non-ECMO arm includes patients suffering from non-early-stage lung cancer undergoing pulmonary resection without planned intraoperative ECMO support.

resultsTwenty patients entered the study, eight in the ECMO arm and twelve in the non-ECMO arm. We did not observe any significant difference between the ECMO and non-ECMO groups in terms of postoperative complications (

conclusionsIntraoperative ECMO for lung cancer resections did not impact CTC increase or decrease after the procedure.

Indexed as

circulating tumor cellsextracorporeal membrane oxygenatorlung cancerlung resection

Identifiers

PMID36291788
PMCPMC9599645
OpenAlexW4306149918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.