Evidence map›Paper›PMID 36291709›Full record

ArticleBiomolecules2022

High-Intensity Exercise Training Improves Basal Platelet Prostacyclin Sensitivity and Potentiates the Response to Dual Anti-Platelet Therapy in Postmenopausal Women.

Kate A Wickham, Line B Nørregaard, Martina H Lundberg Slingsby, Stephen S Cheung, Ylva Hellsten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kate A WickhamAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-2702-6695
Line B NørregaardAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Martina H Lundberg SlingsbyAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Stephen S CheungEnvironmental Ergonomics Lab, Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0002-6149-4978
Ylva HellstenAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
University of Copenhagen · DKBrock University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of thrombotic events dramatically increases with age and may be accelerated in women by the cessation of endogenous estrogen production at menopause. Patients at risk of thrombosis are prescribed dual anti-platelet therapy (DAPT; aspirin and a P2Y

methodsWe assessed prostacyclin sensitivity as well as basal platelet reactivity with and without in vitro DAPT before and after an 8-week high-intensity exercise training program in 13 healthy, sedentary postmenopausal women. The training intervention consisted of three 1 h sessions per week. Isolated platelets were analyzed for thromboxane A

resultsExercise training made platelets more sensitive to the inhibitory effects of prostacyclin on thromboxane-, collagen-, and adenosine 5'-diphosphate (ADP)-induced aggregation, as well as thrombin-receptor activator peptide 6- and ADP-induced aggregation with DAPT. However, there was no change in protein expression from isolated platelets or plasma thromboxane B

conclusionTogether, these findings emphasize the importance of promoting physical activity as a tool for reducing thrombotic risk in postmenopausal women and suggest that training status should be considered when prescribing DAPT in this cohort.

Indexed as

EpoprostenolThrombosisAdenosineAdenosine DiphosphateAspirinCyclooxygenase 1DiphosphatesDual Anti-Platelet TherapyEstrogensExerciseFemaleHumansNitric OxidePeptidesPlatelet Aggregation InhibitorsPostmenopauseAdenosineAdenosine DiphosphateAspirinCyclooxygenase 1DiphosphatesEpoprostenolEstrogensNitric OxidePeptidesPlatelet Aggregation InhibitorsReceptors, EpoprostenolReceptors, ThromboxaneThrombinThromboxanescoagulationdual anti-platelet therapyexercisemenopauseplateletsprostacyclinthrombosis

Identifiers

PMID36291709
PMCPMC9599223
OpenAlexW4306651315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.