ArticleBiomolecules2022
Elucidating the Structural Impacts of Protein InDels.
Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Novel Nona-Repeat in Plasmodium ovale curtisi Circumsporozoite Protein Circulating in Cameroon.Current microbiology · 2025Article
- Energy metric prediction for double insertion mutants via the RoseNet deep learning framework.Bioinformatics advances · 2025Article
- Genome-Wide Identification and Characterization of SNPs and InDels ofPlants (Basel, Switzerland) · 2024Article
- Article
- How pairs of insertion mutations impact protein structure: an exhaustive computational study.Bioinformatics advances · 2024Article
- Editorial: Special Issue "Protein Modeling and Simulation: Selected Articles from the Computational Structural Bioinformatics Workshop 2021".Biomolecules · 2023Article
- Consequences of Genetic Recombination on Protein Folding Stability.Journal of molecular evolution · 2023Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of amino acid insertions and deletions (InDels) remain a rather under-explored area of structural biology. These variations oftentimes are the cause of numerous disease phenotypes. In spite of this, research to study InDels and their structural significance remains limited, primarily due to a lack of experimental information and computational methods. In this work, we fill this gap by modeling InDels computationally; we investigate the rigidity differences between the wildtype and a mutant variant with one or more InDels. Further, we compare how structural effects due to InDels differ from the effects of amino acid substitutions, which are another type of amino acid mutation. We finish by performing a correlation analysis between our rigidity-based metrics and wet lab data for their ability to infer the effects of InDels on protein fitness.
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