Evidence map›Paper›PMID 36291628›Full record

ArticleBiomolecules2022

Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.

Hao Chen, Milorad Tesic, Valentina N Nikolic, Milan Pavlovic, Rada M Vucic, Ana Spasic, Hristina Jovanovic, Ivana Jovanovic, Stephanie E L Town, Matthew P Padula and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Immunology of heart failure with preserved ejection fraction.Expert review of clinical immunology · 2025
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Serum amyloid A in HFpEF and cardiometabolic diseases.Basic research in cardiology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao ChenSchool of Life Sciences & Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Milorad TesicClinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0002-3758-3719
Valentina N NikolicFaculty of Medicine, Department of Pharmacology and Toxicology, University of Nis, 18000 Nis, Serbia.ORCID 0000-0001-7184-0670
Milan PavlovicFaculty of Medicine, Department of Internal Medicine-Cardiology, University of Nis, 18000 Nis, Serbia.
Rada M VucicFaculty of Medical Sciences, Department of Internal Medicine, University of Kragujevac, 34000 Kragujevac, Serbia.
Ana SpasicFaculty of Medicine, Department of Pharmacology and Toxicology, University of Nis, 18000 Nis, Serbia.
Hristina JovanovicFaculty of Medicine, Department of Pharmacology and Toxicology, University of Nis, 18000 Nis, Serbia.
Ivana JovanovicClinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Stephanie E L TownSchool of Life Sciences & Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Matthew P PadulaSchool of Life Sciences & Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0002-8283-0643
Lana McClementsSchool of Life Sciences & Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for around 50% of all heart failure cases. It is a heterogeneous condition with poorly understood pathogenesis. Here, we aimed to identify unique pathogenic mechanisms in acute and chronic HFpEF and hypertrophic cardiomyopathy (HCM). We performed unbiased, comprehensive proteomic analyses of plasma samples from gender- and BMI-matched patients with acute HFpEF (

Indexed as

Heart FailureBiomarkersGlycoproteinsHumansLeucinePhenotypeProteomicsStroke VolumeBiomarkersGlycoproteinsLeucinebiomarkersHCMheart failureheart failure with preserved ejection fractionHFpEFhypertrophic cardiomyopathyplasmaproteomics

Identifiers

PMID36291628
PMCPMC9599828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.