Evidence map›Paper›PMID 36291615›Full record

ArticleBiomolecules2022

A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease.

Rebecca L O'Brien, Jennifer Matsuda, M Kemal Aydintug, Niyun Jin, Swati Phalke, Willi K Born

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. [Gut microbiota dysbiosis in type 1 diabetes mellitus: Impacts, mechanisms, and interventions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca L O'BrienDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-9075-7984
Jennifer MatsudaMouse Genetics Core, National Jewish Health, Denver, CO 80206, USA.
M Kemal AydintugNational Jewish Health, Denver, CO 80206, USA.
Niyun JinDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA.
Swati PhalkeAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.
Willi K BornDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA.
National Jewish Health · USHospital for Special Surgery · US

Funding

Gamma/delta T cells in autoimmune keratitisR01EY021199 · NEI · NATIONAL JEWISH HEALTH · PI O'BRIEN, REBECCA L. · 2012 to 2015
$1.5M
The role of gamma/delta T cells in type 1 diabetesR21AI097962 · NIAID · NATIONAL JEWISH HEALTH · PI O'BRIEN, REBECCA L. · 2012 to 2013
$436k
Discovery and Investigation of Gamma/Delta TCR LigandsR56AI077594 · NIAID · NATIONAL JEWISH HEALTH · PI O'BRIEN, REBECCA L. · 2010 to 2010
$396k
NEI NIH HHS R01 EY021199NIAID NIH HHS R21 AI097962NIAID NIH HHS R56 AI077594
6 · The paper itself

Abstract

Previous studies in mice and humans suggesting that

Indexed as

Diabetes Mellitus, Type 1Receptors, Antigen, T-Cell, gamma-deltaAnimalsHumansInterleukin-17MiceMice, Inbred C57BLMice, Inbred NODT-Lymphocyte SubsetsInterleukin-17Receptors, Antigen, T-Cell, gamma-deltagamma delta T cellsNOD micetype 1 diabetesγδ T cells

Identifiers

PMID36291615
PMCPMC9599391
OpenAlexW4303614084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.