ReviewChildren (Basel, Switzerland)2022
Improved Mortality of Patients with Gastroschisis: A Historical Literature Review of Advances in Surgery and Critical Care from 1960-2020.
Review in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Newborn screening for external congenital anomalies at three public hospitals in Karachi, Pakistan.BMJ paediatrics open · 2026Article
- Digestive congenital anomalies: a call for equity in global neonatal surgical care.Pediatric research · 2026Article
- Trends in Gastroschisis in the State of Paraná, Brazil: A Study of Incidence, Mortality, and Associated Factors (2013-2024).International journal of environmental research and public health · 2026Article
- Gastroschisis: diagnosis, prognosis and treatment options.Frontiers in pediatrics · 2025Review
- Factors associated with death in newborns with gastroschisis: a retrospective cohort study from a single reference center.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Assessment of transfer-time and time-to-surgery as risk factors to survival in Gastroschisis (GS) in a LMIC; an eight-year review.Pediatric surgery international · 2024Article
- Challenges and lessons learnt in the management of an HIV-exposed neonate with gastroschisis in a resource-limited setting: case report.Annals of medicine and surgery (2012) · 2024Article
- Nosocomial Infections Affecting Newborns with Abdominal Wall Defects.Healthcare (Basel, Switzerland) · 2023Article
- miRNA-143 expression is associated with inflammation and time of exposure to amniotic fluid in experimental gastroschisis.Clinics (Sao Paulo, Brazil) · 2023Article
- Factors Affecting Survival of Newborns with Gastroschisis from a Tertiary Care Children's Hospital in India.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The improved survival of gastroschisis patients is a notable pediatric success story. Over the past 60 years, gastroschisis evolved from uniformly fatal to a treatable condition with over 95% survival. We explored the historical effect of four specific clinical innovations—mechanical ventilation, preformed silos, parenteral nutrition, and pulmonary surfactant—that contributed to mortality decline among gastroschisis infants. A literature review was performed to extract mortality rates from six decades of contemporary literature from 1960 to 2020. A total of 2417 publications were screened, and 162 published studies (98,090 patients with gastroschisis) were included. Mortality decreased over time and has largely been <10% since 1993. Mechanical ventilation was introduced in 1965, preformed silo implementation in 1967, parenteral nutrition in 1968, and pulmonary surfactant therapy in 1980. Gastroschisis infants now carry a mortality rate of <5% as a result of these interventions. Other factors, such as timing of delivery, complex gastroschisis, and management in low- and middle-income countries were also explored in relation to gastroschisis mortality. Overall, improved gastroschisis outcomes serve as an illustration of the benefits of clinical advances and multidisciplinary care, leading to a drastic decline in infant mortality among these patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.