Evidence map›Paper›PMID 36291411›Full record

ArticleChildren (Basel, Switzerland)2022

From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants.

Pascal Bedard, Geoffrey L Winsor, Emma S Garlock, Meghan B Azad, Allan B Becker, Piush J Mandhane, Theo J Moraes, Malcolm R Sears, Stuart E Turvey, Padmaja Subbarao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Pascal BedardDepartment of Pharmacy, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Geoffrey L WinsorDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0001-6848-1638
Emma S GarlockDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Meghan B AzadDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3A 1S1, Canada.ORCID 0000-0002-5942-4444
Allan B BeckerDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3A 1S1, Canada.
Piush J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada.
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.ORCID 0000-0001-9968-6601
Malcolm R SearsDepartment of Medicine, McMaster University, Hamilton, ON L8P 1H6, Canada.
Stuart E TurveyDepartment of Pediatrics, BC Children's Hospital and The University of British Columbia, Vancouver, BC V6H 0B3, Canada.
Padmaja SubbaraoDepartment of Pediatrics, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Fiona S L BrinkmanDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0002-0584-4099
Anita L KozyrskyjDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada.ORCID 0000-0002-2869-9242
Simon Fraser University · CAHospital for Sick Children · CAUniversity of Alberta · CACentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital Research Institute of Manitoba · CAMcMaster University · CAUniversity of British Columbia · CAUniversity of Manitoba · CA

Funding

CIHR AEC-85761
6 · The paper itself

Abstract

Limited data exist on pharmaceutical product use by infants, although available data suggests higher prevalence of use among children under 12 months of age. We conducted a descriptive study of 3050 infants recruited in the CHILD Cohort Study, a prospective, multicenter, longitudinal cohort following children from pregnancy through childhood. Parents were surveyed for use of prescription and over-the-counter drugs, and natural health products (NHPs, including homeopathic products and vitamins) at 3, 6, and 12 months after delivery. By one year of age, 96.0% of children had taken at least one pharmaceutical product. Among 307 reported products, 32 were given to at least 1% of cohort infants. Vitamin D, acetaminophen, ibuprofen, topical hydrocortisone, amoxicillin, and nystatin were the most common medications and natural health products (NHPs) received, with 8/32 of the most frequently used products being NHPs. Overall, 14.7% of pharmaceutical products administered to children were off-label and 35.8% were NHPs or products without a Drug Identification Number (DIN). The use of over-the-counter medications and NHPs is common and off-label use of drugs is frequent, even in the first year of life. This study highlights the importance of conducting studies on medication use in infants, and of infant medication use monitoring by healthcare providers.

Indexed as

drugsfamily medicinegeneral practicemedicine and pharmaceutical industrypediatricspharmacyprimary care

Identifiers

PMID36291411
PMCPMC9600175
OpenAlexW4297348297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.