Evidence map›Paper›PMID 36291409›Full record

ReviewChildren (Basel, Switzerland)2022

Hypersensitivity to Intravenous Iron Preparations.

Silvia Caimmi, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Annamaria Bianchi, Paolo Bottau, Francesca Mori, Paolo Triggiano, Claudia Paglialunga, Francesca Saretta and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Treatment for women with postpartum iron deficiency anaemia.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Article
  3. Review
  4. Administration of Intravenous Ferric Carboxymaltose in a Patient With Iron-Deficiency Anemia and Allergy to 2 Oral Iron Preparations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Anemia and Associated Risk Factors in Pediatric Patients.Pediatric health, medicine and therapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Silvia CaimmiUOC Pediatria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0003-0515-524X
Giuseppe CrisafulliUOC Pediatria, Università di Messina, 98124 Messina, Italy.
Fabrizio FranceschiniUOC Pediatria, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", 60020 Ancona, Italy.
Lucia LiottiUOC Pediatria, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", 60020 Ancona, Italy.ORCID 0000-0002-5699-2796
Annamaria BianchiUOC Pediatria, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, Italy.
Paolo BottauDipartimento di Pediatria e Neonatologia, Ospedale di Imola, 40026 Imola, Italy.
Francesca MoriAllergy Unit, Meyer Children's Hospital, 50139 Florence, Italy.
Paolo TriggianoUOC Pediatria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Claudia PaglialungaUOC di Pediatria, Azienda Ospedaliera-Universitaria "Consorziale-Policlinico", Ospedale Pediatrico Giovanni XXIII, 70123 Bari, Italy.
Francesca SarettaSC Pediatria, Ospedale Latisana-Palmanova, Dipartimento Materno-Infantile Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.ORCID 0000-0001-9443-5483
Arianna GiannettiPediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Giampaolo RicciDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Carlo CaffarelliClinica Pediatrica, Azienda Ospedaliero-Universitaria, Dipartimento Medicina e Chirurgia, Università di Parma, 43126 Parma, Italy.
Azienda Ospedaliero Universitaria Ospedali Riuniti · ITPoliclinico San Matteo Fondazione · ITAzienda Ospedaliera San Camillo-Forlanini · ITAzienda USL di Bologna · ITMeyer Children's Hospital · ITOspedale di Latisana · ITOspedale di Parma · ITOspedale Pediatrico Giovanni XXIII · ITUniversity of Bologna · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous iron is widely used for the treatment of iron deficiency anemia when adherence to oral iron replacement is poor. Acute hypersensitivity reactions during iron infusions are very rare but can be life threatening. Major risk factors for hypersensitivity reactions include a previous reaction to an iron infusion, a fast iron infusion rate, multiple drug allergies, atopic diseases, high serum tryptase levels, asthma, and urticaria. The management of iron infusions requires meticulous observation, and, in the event of an adverse reaction, prompt recognition and severity-related interventions by well-trained medical and nursing staff. Avoidance of IV iron products in patients with iron hypersensitivity reactions may not be considered as a standard practice.

Indexed as

desensitizationdrug allergydrug provocation testhypersensitivity reactionironiron hypersensitivity

Identifiers

PMID36291409
PMCPMC9600424
OpenAlexW4297347964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.