Evidence map›Paper›PMID 36291341›Full record

ArticleBrain sciences2022

Odor Pleasantness Modulates Functional Connectivity in the Olfactory Hedonic Processing Network.

Veit Frederik Kepler, Manuel S Seet, Junji Hamano, Mariana Saba, Nitish V Thakor, Stavros I Dimitriadis, Andrei Dragomir

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Veit Frederik KeplerDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore.ORCID 0000-0002-7301-0432
Manuel S SeetThe N.1 Institute of Health, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.ORCID 0000-0003-1807-4035
Junji HamanoInternational Operations, Procter & Gamble, 70 Biopolis Street, Singapore 138547, Singapore.
Mariana SabaInternational Operations, Procter & Gamble, 70 Biopolis Street, Singapore 138547, Singapore.
Nitish V ThakorDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore.ORCID 0000-0002-9981-9395
Stavros I DimitriadisDepartment of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Spain.ORCID 0000-0002-0000-5392
Andrei DragomirThe N.1 Institute of Health, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.ORCID 0000-0003-2815-6958
National University of Singapore · SGJohns Hopkins University · USUniversitat de Barcelona · ES

Funding

Agency for Science, Technology and Research APG2013/110Procter and Gamble APG2013/131
6 · The paper itself

Abstract

Olfactory hedonic evaluation is the primary dimension of olfactory perception and thus central to our sense of smell. It involves complex interactions between brain regions associated with sensory, affective and reward processing. Despite a recent increase in interest, several aspects of olfactory hedonic evaluation remain ambiguous: uncertainty surrounds the communication between, and interaction among, brain areas during hedonic evaluation of olfactory stimuli with different levels of pleasantness, as well as the corresponding supporting oscillatory mechanisms. In our study we investigated changes in functional interactions among brain areas in response to odor stimuli using electroencephalography (EEG). To this goal, functional connectivity networks were estimated based on phase synchronization between EEG signals using the weighted phase lag index (wPLI). Graph theoretic metrics were subsequently used to quantify the resulting changes in functional connectivity of relevant brain regions involved in olfactory hedonic evaluation. Our results indicate that odor stimuli of different hedonic values evoke significantly different interaction patterns among brain regions within the olfactory cortex, as well as in the anterior cingulate and orbitofrontal cortices. Furthermore, significant hemispheric laterality effects have been observed in the prefrontal and anterior cingulate cortices, specifically in the beta ((13-30) Hz) and gamma ((30-40) Hz) frequency bands.

Indexed as

brain connectivityelectroencephalographyhedonic evaluationlateralizationolfaction

Identifiers

PMID36291341
PMCPMC9599424
OpenAlexW4306839756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.