Evidence map›Paper›PMID 36291316›Full record

ArticleBrain sciences2022

Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation.

Lynn Marquardt, Alexander R Craven, Kenneth Hugdahl, Erik Johnsen, Rune Andreas Kroken, Isabella Kusztrits, Karsten Specht, Anne Synnøve Thomassen, Sarah Weber, Marco Hirnstein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 4 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lynn MarquardtDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.
Alexander R CravenDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.ORCID 0000-0003-2583-7571
Kenneth HugdahlDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.
Erik JohnsenNORMENT Center of Excellence, University of Bergen and Haukeland University Hospital, 5009 Bergen, Norway.
Rune Andreas KrokenNORMENT Center of Excellence, University of Bergen and Haukeland University Hospital, 5009 Bergen, Norway.
Isabella KusztritsDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.
Karsten SpechtDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.ORCID 0000-0002-9946-3704
Anne Synnøve ThomassenDivision of Psychiatry, Haukeland University Hospital, 5021 Bergen, Norway.
Sarah WeberDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.
Marco HirnsteinDepartment of Biological and Medical Psychology, University of Bergen, 5009 Bergen, Norway.ORCID 0000-0002-6291-0929
Haukeland University Hospital · NOHøyskolen Kristiania · NO

Funding

Bergen Research Foundation BFS2016REK03
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS

methodsA double-blind, randomized controlled trial was conducted with 21 patients receiving either sham or real tDCS treatment (2 mA) twice daily for 5 days. The anode was placed over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the left temporo-parietal cortex (TPC). Multimodal neuroimaging as well as clinical and neurocognitive functioning assessment were performed before, immediately after, and three months after treatment.

resultsWe found a small reduction in AVH severity in the real tDCS group, but no corresponding neuroimaging changes in either DLPFCD or TPC. LIMITATIONS: The study has a small sample size.

conclusionThe results suggest that the currently leading theory behind tDCS treatment of AVH may need to be revised, if confirmed by studies with larger N. Tentative findings point to the involvement of Broca's area as a critical structure for tDCS treatment.

Indexed as

brain stimulationMR spectroscopyresting-state functional MRI (fMRI)schizophreniastructural MRtask-related fMRI

Identifiers

PMID36291316
PMCPMC9599056
OpenAlexW4304806841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.