ArticleBrain sciences2022
Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Associations Between Cognitive Performance and Motor Signs in Older Adults with Alzheimer's Dementia.Medicina (Kaunas, Lithuania) · 2025Article
- Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.European geriatric medicine · 2025Article
- Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.International journal of geriatric psychiatry · 2025Article
- Motor symptoms in autopsy-confirmed Alzheimer's disease increase the risk of progression to severe cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.Journal of the American Geriatrics Society · 2025Article
- Neuropsychiatric Symptoms Associated With Frontotemporal Atrophy in Older Adults Without Dementia.International journal of geriatric psychiatry · 2024Article
- Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database.Aging clinical and experimental research · 2024Article
- Neurocognitive Impairment and Social Cognition in Parkinson's Disease Patients.Neurology international · 2024Review
- Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment.Psychiatry and clinical neurosciences · 2024Article
- Cognitive Performance and Incident Alzheimer's Dementia in Men Versus Women.The journal of prevention of Alzheimer's disease · 2024Article
- Associations between neuropsychiatric symptoms and incident Alzheimer's dementia in men versus women.Journal of neurology · 2023Article
- Learned Irrelevance, Perseveration, and Cognitive Aging: A Cross-Sectional Study of Cognitively Unimpaired Older Adults.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the baseline evaluations of older, CU participants from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. In total, 8149 CU (≥60 years) participants were included. Of these, 905 individuals scored ≥ 2 on at least one of the motor domains of the Unified Parkinson's Disease Rating Scale part III (UPDRSIII). Cognitively impaired individuals, participants with psychiatric disorders and/or under treatment with antipsychotic, anxiolytic, sedative or hypnotic agents were excluded. Nine motor signs were examined: hypophonia, masked facies, resting tremor, action/postural tremor, rigidity, bradykinesia, impaired chair rise, impaired posture/gait and postural instability. Their association with performance on episodic memory, semantic memory, language, attention, processing speed or executive function was assessed using crude and adjusted linear regression models. Individuals with impaired chair rise had worse episodic memory, semantic memory, processing speed and executive function, while those with bradykinesia had worse language, processing speed and executive function. Sensitivity analyses, by excluding participants with cerebrovascular disease or PD, or other Parkinsonism, produced similar results with the exception of the relationship between bradykinesia and language performance.
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Registered trials
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